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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 24 — Nov. 21, 2011
  • pp: 24078–24089

Real-time, subsecond, multicomponent breath analysis by Optical Parametric Oscillator based Off-Axis Integrated Cavity Output Spectroscopy

Denis D. Arslanov, Koen Swinkels, Simona M. Cristescu, and Frans J. M. Harren  »View Author Affiliations


Optics Express, Vol. 19, Issue 24, pp. 24078-24089 (2011)
http://dx.doi.org/10.1364/OE.19.024078


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Abstract

Breath analysis is an attractive field of research, due to its high potential for non-invasive medical diagnostics. Among others, laser-based absorption spectroscopy is an excellent method for the detection of gases in exhaled breath, because it can combine a high sensitivity with a good selectivity, and a high temporal resolution. Here, we use a fast-scanning continuous wave, singly-resonant Optical Parametric Oscillator (wavelength range between 3 and 4 μm, linewidth 40 MHz, output power > 1 W, scanning speed 100 THz/s) with Off-Axis Integrated Cavity Output Spectroscopy for rapid and sensitive trace gas detection. Real-time, low- ppbv detection of ethane is demonstrated in exhaled human breath during free exhalations. Also, simultaneous, real-time multi-component gas detection of ethane, methane and water was performed in exhaled breath using a wide spectral coverage over 17 cm−1 in 1 second. Furthermore, real-time detection of acetone, a molecule with a wide absorption spectrum, was shown in exhaled breath, with a sub-second time resolution (0.4 s).

© 2011 OSA

OCIS Codes
(140.0140) Lasers and laser optics : Lasers and laser optics
(190.4410) Nonlinear optics : Nonlinear optics, parametric processes
(190.4970) Nonlinear optics : Parametric oscillators and amplifiers
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(190.4975) Nonlinear optics : Parametric processes

ToC Category:
Sensors

History
Original Manuscript: September 8, 2011
Revised Manuscript: October 15, 2011
Manuscript Accepted: October 30, 2011
Published: November 10, 2011

Virtual Issues
Vol. 7, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Denis D. Arslanov, Koen Swinkels, Simona M. Cristescu, and Frans J. M. Harren, "Real-time, subsecond, multicomponent breath analysis by Optical Parametric Oscillator based Off-Axis Integrated Cavity Output Spectroscopy," Opt. Express 19, 24078-24089 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-24-24078


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