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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 25 — Dec. 5, 2011
  • pp: 25161–25172

Vertical optical sectioning using a magnetically driven confocal microscanner aimed for in vivo clinical imaging

Hadi Mansoor, Haishan Zeng, Keqin Chen, Yingqiu Yu, Jianhua Zhao, and Mu Chiao  »View Author Affiliations


Optics Express, Vol. 19, Issue 25, pp. 25161-25172 (2011)
http://dx.doi.org/10.1364/OE.19.025161


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Abstract

This paper presents a confocal microscanner for direct vertical optical sectioning of biological samples. Confocal imaging is performed by transverse (X-axis) and axial (Z-axis) scanning of a focused laser beam using an optical fiber and a microlens respectively. The actuators are fabricated by laser micromachining techniques and are driven by electromagnetic forces. Optical and mechanical performance of the system is predicted by simulation software packages and characterized by experimental measurements. The scanner has lateral resolution of 3.87 µm and axial resolution of 10.68 µm with a field of view of 145 µm in X and 190 µm in Z directions. Confocal imaging of a polymer layer deposited on a silicon wafer and onion epidermal cells is demonstrated.

© 2011 OSA

OCIS Codes
(110.2350) Imaging systems : Fiber optics imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(180.1790) Microscopy : Confocal microscopy
(230.4685) Optical devices : Optical microelectromechanical devices

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 30, 2011
Revised Manuscript: October 26, 2011
Manuscript Accepted: November 14, 2011
Published: November 23, 2011

Virtual Issues
Vol. 7, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Hadi Mansoor, Haishan Zeng, Keqin Chen, Yingqiu Yu, Jianhua Zhao, and Mu Chiao, "Vertical optical sectioning using a magnetically driven confocal microscanner aimed for in vivo clinical imaging," Opt. Express 19, 25161-25172 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-25-25161


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