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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 3 — Jan. 31, 2011
  • pp: 2093–2104

Passive element enriched photoacoustic computed tomography (PER PACT) for simultaneous imaging of acoustic propagation properties and light absorption

Jithin Jose, Rene G. H. Willemink, Steffen Resink, Daniele Piras, J. C. G van Hespen, Cornelis H. Slump, Wiendelt Steenbergen, Ton G. van Leeuwen, and Srirang Manohar  »View Author Affiliations


Optics Express, Vol. 19, Issue 3, pp. 2093-2104 (2011)
http://dx.doi.org/10.1364/OE.19.002093


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Abstract

We present a ‘hybrid’ imaging approach which can image both light absorption properties and acoustic transmission properties of an object in a two-dimensional slice using a computed tomography (CT) photoacoustic imager. The ultrasound transmission measurement method uses a strong optical absorber of small cross-section placed in the path of the light illuminating the sample. This absorber, which we call a passive element acts as a source of ultrasound. The interaction of ultrasound with the sample can be measured in transmission, using the same ultrasound detector used for photoacoustics. Such measurements are made at various angles around the sample in a CT approach. Images of the ultrasound propagation parameters, attenuation and speed of sound, can be reconstructed by inversion of a measurement model. We validate the method on specially designed phantoms and biological specimens. The obtained images are quantitative in terms of the shape, size, location, and acoustic properties of the examined heterogeneities.

© 2011 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 1, 2010
Revised Manuscript: November 2, 2010
Manuscript Accepted: November 8, 2010
Published: January 20, 2011

Virtual Issues
Vol. 6, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Jithin Jose, Rene G. H. Willemink, Steffen Resink, Daniele Piras, J. C. G van Hespen, Cornelis H. Slump, Wiendelt Steenbergen, Ton G. van Leeuwen, and Srirang Manohar, "Passive element enriched photoacoustic computed tomography (PER PACT) for simultaneous imaging of acoustic propagation properties and light absorption," Opt. Express 19, 2093-2104 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-3-2093


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References

  1. L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009). [CrossRef]
  2. S. Manohar, S. E. Vaartjes, J. C. G. van Hespen, J. M. Klaase, F. M. van den Engh, W. Steenbergen, and T. G. van Leeuwen, “Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics,” Opt. Express 15(19), 12277–12285 (2007), http://www.opticsinfobase.org/abstract.cfm?URI=oe-15-19-12277 . [CrossRef] [PubMed]
  3. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009). [CrossRef] [PubMed]
  4. T. D. Khokhlova, I. M. Pelivanov, V. V. Kozhushko, A. N. Zharinov, V. S. Solomatin, and A. A. Karabutov, “Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics,” Appl. Opt. 46(2), 262–272 (2007). [CrossRef] [PubMed]
  5. J. Jose, S. Manohar, R. G. M. Kolkman, W. Steenbergen, and T. G. van Leeuwen, “Imaging of tumor vasculature using Twente photoacoustic systems,” J Biophoton. 2(12), 701–717 (2009). [CrossRef]
  6. J. T. Oh, M. L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 34032 (2006). [CrossRef] [PubMed]
  7. R. Nuster, M. Holotta, C. Kremser, H. Grossauer, P. Burgholzer, and G. Paltauf, “Photoacoustic microtomography using optical interferometric detection,” J. Biomed. Opt. 15(2), 021307 (2010). [CrossRef] [PubMed]
  8. J. Laufer, E. Zhang, G. Raivich, and P. Beard, “Three-dimensional noninvasive imaging of the vasculature in the mouse brain using a high resolution photoacoustic scanner,” Appl. Opt. 48(10), D299–D306 (2009). [CrossRef] [PubMed]
  9. H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009). [CrossRef]
  10. R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express 17(24), 21414–21426 (2009), http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-24-21414 . [CrossRef] [PubMed]
  11. M. H. Xu and L. H. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrumn. 77, (2006).
  12. X. Jin and L. V. Wang, “Thermoacoustic tomography with correction for acoustic speed variations,” Phys. Med. Biol. 51(24), 6437–6448 (2006). [CrossRef] [PubMed]
  13. J. F. Greenleaf and R. C. Bahn, “Clinical imaging with transmissive ultrasonic computerized tomography,” IEEE Trans. Biomed. Eng. 28(2), 177–185 (1981). [CrossRef] [PubMed]
  14. N. Duric, P. Littrup, L. Poulo, A. Babkin, R. Pevzner, E. Holsapple, O. Rama, and C. Glide, “Detection of breast cancer with ultrasound tomography: first results with the Computed Ultrasound Risk Evaluation (CURE) prototype,” Med. Phys. 34(2), 773–785 (2007). [CrossRef] [PubMed]
  15. S. Manohar, R. G. H. Willemink, and T. G. van Leeuwen, “Speed-of-sound imaging in a photoacoustic imager,” SPIE (2007), 64370R. [CrossRef]
  16. S. Manohar, R. G. H. Willemink, F. van der Heijden, C. H. Slump, and T. G. van Leeuwen, “Concomitant speed-of-sound tomography in photoacoustic imaging,” Appl. Phys. Lett. 91 (2007).
  17. R. G. H. Willemink, S. Manohar, Y. Purwar, C. H. Slump, F. d. Heijden, and T. G. v. Leeuwen, “Imaging of acoustic attenuation and speed of sound maps using photoacoustic measurements,” in (SPIE, 2008), 692013.
  18. P. M. Joseph and R. A. Schulz, “View sampling requirements in fan beam computed tomography,” Med. Phys. 7(6), 692–702 (1980). [CrossRef] [PubMed]
  19. F. Marinozzi, D. Piras, and F. Bini, “Spectral analysis of backscattered ultrasound field from hydroxyapatite granules,” in Advances in Medical, Signal and Information Processing, 2008. MEDSIP 2008. 4th IET International Conference on, 2008), 1–4.
  20. J. C. Bamber, Acoustical characteristics of biological media (Encyclopedia of acoustics, Wiley, 1997), Vol. 4.
  21. R. G. H. Willemink, S. Manohar, T. G. van Leeuwen, and C. H. Slump, “Estimation of integrated ultrasound transmission parameters I,” Speed of Sound under review.
  22. R. G. H. Willemink, S. Manohar, C. H. Slump, F. van der Heijden, and T. G. van Leeuwen, “A maximum likelihood method for obtaining integrated attenuation from ultrasound transmission mode measurement,” J. Acoust. Soc. Am. 123(5), 3641 (2008). [CrossRef]
  23. R. G. H. Willemink, S. Manohar, T. G. van Leeuwen, and C. H. Slump, “Estimation of integrated ultrasound transmission parameters II: Acoustic attenuation,” in preparation.
  24. R. A. Kruger, P. Liu, Y. R. Fang, and C. R. Appledorn, “Photoacoustic ultrasound (PAUS)--reconstruction tomography,” Med. Phys. 22(10), 1605–1609 (1995). [CrossRef] [PubMed]
  25. C. R. Crawford and A. C. Kak, “Multipath artifact corrections in ultrasonic transmission tomography,” Ultrason. Imaging 4(3), 234–266 (1982). [CrossRef] [PubMed]
  26. R. G. H. Willemink, S. Manohar, J. Jose, C. H. Slump, F. van der Heijden, and T. G. van Leeuwen, Simultaneous imaging of ultrasound attenuation, speed of sound, and optical absorption in a photoacoustic setup,” A. M. Stephen and D. h. Jan, eds. (SPIE, 2009), p. 72650J.

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