Miniaturized optoelectronic tweezers controlled by GaN micro-pixel light emitting diode arrays

doi:10.1364/OE.19.002720

Miniaturized optoelectronic tweezers controlled by GaN micro-pixel light emitting diode arrays

Alicja Zarowna-Dabrowska, Steven L. Neale, David Massoubre, Jonathan McKendry, Bruce R. Rae, Robert K. Henderson, Mervyn J. Rose, Huabing Yin, Jonathan M. Cooper, Erdan Gu, and Martin D. Dawson »View Author Affiliations

Optics Express, Vol. 19, Issue 3, pp. 2720-2728 (2011)
http://dx.doi.org/10.1364/OE.19.002720

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Abstract
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Abstract

A novel, miniaturized optoelectronic tweezers (OET) system has been developed using a CMOS-controlled GaN micro-pixelated light emitting diode (LED) array as an integrated micro-light source. The micro-LED array offers spatio-temporal and intensity control of the emission pattern, enabling the creation of reconfigurable virtual electrodes to achieve OET. In order to analyse the mechanism responsible for particle manipulation in this OET system, the average particle velocity, electrical field and forces applied to the particles were characterized and simulated. The capability of this miniaturized OET system for manipulating and trapping multiple particles including polystyrene beads and live cells has been successfully demonstrated.

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(230.0250) Optical devices : Optoelectronics
(230.3670) Optical devices : Light-emitting diodes
(230.3990) Optical devices : Micro-optical devices
(350.4855) Other areas of optics : Optical tweezers or optical manipulation
(230.6046) Optical devices : Smart pixel systems

ToC Category:
Optical Trapping and Manipulation

History
Original Manuscript: December 8, 2010
Revised Manuscript: January 17, 2011
Manuscript Accepted: January 21, 2011
Published: January 27, 2011

Virtual Issues
Vol. 6, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Alicja Zarowna-Dabrowska, Steven L. Neale, David Massoubre, Jonathan McKendry, Bruce R. Rae, Robert K. Henderson, Mervyn J. Rose, Huabing Yin, Jonathan M. Cooper, Erdan Gu, and Martin D. Dawson, "Miniaturized optoelectronic tweezers controlled by GaN micro-pixel light emitting diode arrays," Opt. Express 19, 2720-2728 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-3-2720

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References

H. Xie, D. S. Haliyo, and S. Régnier, “A versatile atomic force microscope for three-dimensional nanomanipulation and nanoassembly,” Nanotechnology 20(21), 215301 (2009). [CrossRef] [PubMed]
D. J. Stevenson, F. Gunn-Moore, and K. Dholakia, “Light forces the pace: optical manipulation for biophotonics,” J. Biomed. Opt. 15(4), 041503 (2010). [CrossRef] [PubMed]
R. Pethig, “Review Article-Dielectrophoresis: Status of the theory, technology, and applications,” Biomicrofluidics 4(2), 022811 (2010). [CrossRef]
G. Vieira, T. Henighan, A. Chen, A. J. Hauser, F. Y. Yang, J. J. Chalmers, and R. Sooryakumar, “Magnetic wire traps and programmable manipulation of biological cells,” Phys. Rev. Lett. 103(12), 128101 (2009). [CrossRef] [PubMed]
Y. Yamakoshi, Y. Koitabashi, N. Nakajima, and T. Miwa, “Yeast cell trapping in ultrasonic wave field using ultrasonic contrast agent,” Jpn. J. Appl. Phys. Part 1 - Regul, Pap. Brief Commun. Rev. Pap. 45, 4712–4717 (2006).
P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005). [CrossRef] [PubMed]
S. L. Neale, M. Mazilu, J. I. B. Wilson, K. Dholakia, and T. F. Krauss, “The resolution of optical traps created by Light Induced Dielectrophoresis (LIDEP),” Opt. Express 15(20), 12619–12626 (2007). [CrossRef] [PubMed]
H. Hwang, Y. J. Choi, W. Choi, S. H. Kim, J. Jang, and J. K. Park, “Interactive manipulation of blood cells using a lens-integrated liquid crystal display based optoelectronic tweezers system,” Electrophoresis 29(6), 1203–1212 (2008). [CrossRef] [PubMed]
J. K. Valley, A. Jamshidi, A. T. Ohta, H. Y. Hsu, and M. C. Wu, “Operational regimes and physics present in optoelectronic tweezers,” J. Microelectromech. Syst. 17(2), 342–350 (2008). [CrossRef] [PubMed]
J. J. D. McKendry, R. P. Green, A. E. Kelly, Z. Gong, B. Guilhabert, D. Massoubre, E. D. Gu, and M. D. Dawson, “High-Speed Visible Light Communications Using Individual Pixels in a Micro Light-Emitting Diode Array,” IEEE Photon. Technol. Lett. 22(18), 1346–1348 (2010). [CrossRef]
T. Kamei, B. M. Paegel, J. R. Scherer, A. M. Skelley, R. A. Street, and R. A. Mathies, “Integrated hydrogenated amorphous Si photodiode detector for microfluidic bioanalytical devices,” Anal. Chem. 75(20), 5300–5305 (2003). [CrossRef]
R. A. Street, Technology and Applications of Amorphous Silicon (Springer, New York, 2000).
J. K. Valley, S. Neale, H. Y. Hsu, A. T. Ohta, A. Jamshidi, and M. C. Wu, “Parallel single-cell light-induced electroporation and dielectrophoretic manipulation,” Lab Chip 9(12), 1714–1720 (2009). [CrossRef] [PubMed]
B. R. Rae, K. R. Muir, Z. Gong, J. McKendry, J. M. Girkin, E. Gu, D. Renshaw, M. D. Dawson, and R. K. Henderson, “A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System,” Sensors 9(11), 9255–9274 (2009). [CrossRef]

Chalmers, J. J.
Chen, A.
Chiou, P. Y.
Choi, W.
Choi, Y. J.
Dawson, M. D.
Dholakia, K.
Girkin, J. M.
Gong, Z.
Green, R. P.
Gu, E.
Gu, E. D.
Guilhabert, B.
Gunn-Moore, F.
Haliyo, D. S.
Hauser, A. J.
Henderson, R. K.
Henighan, T.
Hsu, H. Y.
Hwang, H.
Jamshidi, A.
Jang, J.
Kamei, T.
Kelly, A. E.
Kim, S. H.
Koitabashi, Y.
Krauss, T. F.
Massoubre, D.
Mathies, R. A.
Mazilu, M.
McKendry, J.
McKendry, J. J. D.
Miwa, T.
Muir, K. R.
Nakajima, N.
Neale, S.
Neale, S. L.
Ohta, A. T.
Paegel, B. M.
Park, J. K.
Pethig, R.
Rae, B. R.
Régnier, S.
Renshaw, D.
Scherer, J. R.
Skelley, A. M.
Sooryakumar, R.
Stevenson, D. J.
Street, R. A.
Valley, J. K.
Vieira, G.
Wilson, J. I. B.
Wu, M. C.
Xie, H.
Yamakoshi, Y.
Yang, F. Y.

Anal. Chem.

T. Kamei, B. M. Paegel, J. R. Scherer, A. M. Skelley, R. A. Street, and R. A. Mathies, “Integrated hydrogenated amorphous Si photodiode detector for microfluidic bioanalytical devices,” Anal. Chem. 75(20), 5300–5305 (2003). [CrossRef]

Biomicrofluidics

R. Pethig, “Review Article-Dielectrophoresis: Status of the theory, technology, and applications,” Biomicrofluidics 4(2), 022811 (2010). [CrossRef]

Electrophoresis

H. Hwang, Y. J. Choi, W. Choi, S. H. Kim, J. Jang, and J. K. Park, “Interactive manipulation of blood cells using a lens-integrated liquid crystal display based optoelectronic tweezers system,” Electrophoresis 29(6), 1203–1212 (2008). [CrossRef] [PubMed]

IEEE Photon. Technol. Lett.

J. J. D. McKendry, R. P. Green, A. E. Kelly, Z. Gong, B. Guilhabert, D. Massoubre, E. D. Gu, and M. D. Dawson, “High-Speed Visible Light Communications Using Individual Pixels in a Micro Light-Emitting Diode Array,” IEEE Photon. Technol. Lett. 22(18), 1346–1348 (2010). [CrossRef]

J. Biomed. Opt.

D. J. Stevenson, F. Gunn-Moore, and K. Dholakia, “Light forces the pace: optical manipulation for biophotonics,” J. Biomed. Opt. 15(4), 041503 (2010). [CrossRef] [PubMed]

J. Microelectromech. Syst.

J. K. Valley, A. Jamshidi, A. T. Ohta, H. Y. Hsu, and M. C. Wu, “Operational regimes and physics present in optoelectronic tweezers,” J. Microelectromech. Syst. 17(2), 342–350 (2008). [CrossRef] [PubMed]

Jpn. J. Appl. Phys. Part 1 - Regul, Pap. Brief Commun. Rev. Pap.

Y. Yamakoshi, Y. Koitabashi, N. Nakajima, and T. Miwa, “Yeast cell trapping in ultrasonic wave field using ultrasonic contrast agent,” Jpn. J. Appl. Phys. Part 1 - Regul, Pap. Brief Commun. Rev. Pap. 45, 4712–4717 (2006).

Lab Chip

J. K. Valley, S. Neale, H. Y. Hsu, A. T. Ohta, A. Jamshidi, and M. C. Wu, “Parallel single-cell light-induced electroporation and dielectrophoretic manipulation,” Lab Chip 9(12), 1714–1720 (2009). [CrossRef] [PubMed]

Nanotechnology

H. Xie, D. S. Haliyo, and S. Régnier, “A versatile atomic force microscope for three-dimensional nanomanipulation and nanoassembly,” Nanotechnology 20(21), 215301 (2009). [CrossRef] [PubMed]

Nature

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005). [CrossRef] [PubMed]

Opt. Express

S. L. Neale, M. Mazilu, J. I. B. Wilson, K. Dholakia, and T. F. Krauss, “The resolution of optical traps created by Light Induced Dielectrophoresis (LIDEP),” Opt. Express 15(20), 12619–12626 (2007). [CrossRef] [PubMed]

Phys. Rev. Lett.

G. Vieira, T. Henighan, A. Chen, A. J. Hauser, F. Y. Yang, J. J. Chalmers, and R. Sooryakumar, “Magnetic wire traps and programmable manipulation of biological cells,” Phys. Rev. Lett. 103(12), 128101 (2009). [CrossRef] [PubMed]

Sensors

B. R. Rae, K. R. Muir, Z. Gong, J. McKendry, J. M. Girkin, E. Gu, D. Renshaw, M. D. Dawson, and R. K. Henderson, “A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System,” Sensors 9(11), 9255–9274 (2009). [CrossRef]

Other

R. A. Street, Technology and Applications of Amorphous Silicon (Springer, New York, 2000).

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