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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 5 — Feb. 28, 2011
  • pp: 4009–4016

Molecular imaging with terahertz waves

Seung Jae Oh, Jihye Choi, Inhee Maeng, Jae Yeon Park, Kwangyeol Lee, Yong-Min Huh, Jin-Suck Suh, Seungjoo Haam, and Joo-Hiuk Son  »View Author Affiliations


Optics Express, Vol. 19, Issue 5, pp. 4009-4016 (2011)
http://dx.doi.org/10.1364/OE.19.004009


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Abstract

We demonstrate a highly sensitive THz molecular imaging (TMI) technique involving differential modulation of surface plasmons induced on nanoparticles and obtain target specific in vivo images of cancers. This technique can detect quantities of gold nanoparticles as small as 15 µM in vivo. A comparison of TMI images with near infrared absorption images shows the superior sensitivity of TMI. Furthermore, the quantification property of TMI is excellent, being linearly proportional to the concentration of nanoparticles. The target specificity issue is also addressed at the ex vivo and cell levels. The high thermal sensitivity of TMI can help extend photonic-based photothermal molecular imaging researches from the in vitro level to the in vivo level. The TMI technique can be used for monitoring drug delivery processes and for early cancer diagnosis.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6795) Medical optics and biotechnology : Terahertz imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 20, 2010
Revised Manuscript: February 2, 2011
Manuscript Accepted: February 2, 2011
Published: February 15, 2011

Virtual Issues
Vol. 6, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Seung Jae Oh, Jihye Choi, Inhee Maeng, Jae Yeon Park, Kwangyeol Lee, Yong-Min Huh, Jin-Suck Suh, Seungjoo Haam, and Joo-Hiuk Son, "Molecular imaging with terahertz waves," Opt. Express 19, 4009-4016 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-5-4009


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