OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 5 — Feb. 28, 2011
  • pp: 4521–4527

White-light spectral interferometry for surface plasmon resonance sensing applications

Siu Pang Ng, Chi Man Lawrence Wu, Shu Yuen Wu, and Ho Pui Ho  »View Author Affiliations

Optics Express, Vol. 19, Issue 5, pp. 4521-4527 (2011)

View Full Text Article

Enhanced HTML    Acrobat PDF (1024 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



A novel differential phase detecting surface plasmon resonance (SPR) sensor based on white-light spectral interferometry is presented. Our proposed scheme employs a white-light source for SPR excitation and measures the corresponding SPR phase change at the optimized coupling wavelength with fixed angle of incidence across the visible spectrum. Compared to existing laser based phase detecting schemes, this system offers optimal sensitivity and extended dynamic range of measurement without any compromise in phase detection resolution. Results obtained from sodium chloride solutions indicate that the detection limit is 2.6 × 10−7 RIU over a refractive index range of 10−2 RIU, which is considerably wider than that achievable by existing laser based approach, thus making our scheme very attractive for practical SPR sensing applications.

© 2011 OSA

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 12, 2011
Revised Manuscript: February 7, 2011
Manuscript Accepted: February 16, 2011
Published: February 23, 2011

Virtual Issues
Vol. 6, Iss. 3 Virtual Journal for Biomedical Optics

Siu Pang Ng, Chi Man Lawrence Wu, Shu Yuen Wu, and Ho Pui Ho, "White-light spectral interferometry for surface plasmon resonance sensing applications," Opt. Express 19, 4521-4527 (2011)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. J. Homola, Surface Plasmon Resonance Based Sensors, Springer Series on Chemical Sensors and Biosensors (Springer-Verlag, 2006).
  2. M. Piliarik and J. Homola, “Surface plasmon resonance (SPR) sensors: approaching their limits?” Opt. Express 17(19), 16505–16517 (2009). [CrossRef] [PubMed]
  3. S. Y. Wu, H. P. Ho, W. C. Law, C. Lin, and S. K. Kong, “Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach-Zehnder configuration,” Opt. Lett. 29(20), 2378–2380 (2004). [CrossRef] [PubMed]
  4. A. V. Kabashin and P. I. Nikitin, “Surface plasmon resonance interferometer for bio- and chemical-sensors,” Opt. Commun. 150(1-6), 5–8 (1998). [CrossRef]
  5. A. V. Kabashin, S. Patskovsky, and A. N. Grigorenko, “Phase and amplitude sensitivities in surface plasmon resonance bio and chemical sensing,” Opt. Express 17(23), 21191–21204 (2009). [CrossRef] [PubMed]
  6. W. C. Law, P. Markowicz, K. T. Yong, I. Roy, A. Baev, S. Patskovsky, A. V. Kabashin, H. P. Ho, and P. N. Prasad, “Wide dynamic range phase-sensitive surface plasmon resonance biosensor based on measuring the modulation harmonics,” Biosens. Bioelectron. 23(5), 627–632 (2007). [CrossRef] [PubMed]
  7. P. P. Markowicz, W. C. Law, A. Baev, P. N. Prasad, S. Patskovsky, and A. V. Kabashin, “Phase-sensitive time-modulated surface plasmon resonance polarimetry for wide dynamic range biosensing,” Opt. Express 15(4), 1745–1754 (2007). [CrossRef] [PubMed]
  8. S. P. Ng, C. M. L. Wu, S. Y. Wu, H. P. Ho, and S. K. Kong, “Differential spectral phase interferometry for wide dynamic range surface plasmon resonance biosensing,” Biosens. Bioelectron. 26(4), 1593–1598 (2010). [CrossRef] [PubMed]
  9. S. P. Ng, S. Y. Wu, H. P. Ho, and C. M. L. Wu, “A white-light interferometric surface plasmon resonance sensor with wide dynamic range and phase-sensitive response,” IEEE International Conference on Electron Devices and Solid-State Circuits, December 2008, HKSAR.
  10. G. G. Nenninger, M. Piliarik, and J. Homola, “Data analysis for optical sensors based on spectroscopy of surface plasmons,” Meas. Sci. Technol. 13(12), 2038–2046 (2002). [CrossRef]
  11. L. Mandel, and E. Wolf, Optical Coherence and Quantum Optics, (Cambridge University Press, 1995).
  12. P. Hlubina, D. Ciprian, and J. Lunacek, “Spectral interferometric technique to measure the ellipsometric phase of a thin-film structure,” Opt. Lett. 34(17), 2661–2663 (2009). [CrossRef] [PubMed]
  13. http://refractiveindex.info/
  14. D. R. Lide ed., CRC Handbook of Chemistry and Physics, 90th ed. (CRC Press, 2010).
  15. W. Yuan, H. P. Ho, C. L. Wong, S. K. Kong, and C. Lin, “Surface plasmon resonance biosensor incorporated in a Michelson interferometer with enhanced sensitivity,” IEEE Sens. J. 7(1), 70–73 (2007). [CrossRef]
  16. H. P. Ho, S. Y. Wu, M. Yang, and A. C. Cheung, “Application of white light-emitting diode to surface plasmon resonance sensors,” Sens. Actuators B Chem. 80(2), 89–94 (2001). [CrossRef]
  17. P. Hlubina, J. Lunacek, D. Ciprian, and R. Chlebus, “Windowed Fourier transform applied in the wavelength domain to process the spectral interference signals,” Opt. Commun. 281(9), 2349–2354 (2008). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited