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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 5 — Feb. 28, 2011
  • pp: 4644–4652

Improved detection sensitivity of D-mannitol crystalline phase content using differential spectral phase shift terahertz spectroscopy measurements

Jean-François Allard, Alain Cornet, Christophe Debacq, Marc Meurens, Daniel Houde, and Denis Morris  »View Author Affiliations


Optics Express, Vol. 19, Issue 5, pp. 4644-4652 (2011)
http://dx.doi.org/10.1364/OE.19.004644


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Abstract

We report quantitative measurement of the relative proportion of δ- and β- D-mannitol crystalline phases inserted into polyethylene powder pellets, obtained by time-domain terahertz spectroscopy. Nine absorption bands have been identified from 0.2 THz to 2.2 THz. The best quantification of the δ-phase proportion is made using the 1.01 THz absorption band. Coherent detection allows using the spectral phase shift of the transmitted THz waveform to improve the detection sensitivity of the relative δ-phase proportion. We argue that differential phase shift measurements are less sensitive to samples' defects. Using a linear phase shift compensation for pellets of slightly different thicknesses, we were able to distinguish a 0.5% variation in δ-phase proportion.

© 2011 OSA

OCIS Codes
(030.1640) Coherence and statistical optics : Coherence
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(300.6495) Spectroscopy : Spectroscopy, teraherz

ToC Category:
Spectroscopy

History
Original Manuscript: December 15, 2010
Revised Manuscript: February 3, 2011
Manuscript Accepted: February 9, 2011
Published: February 24, 2011

Virtual Issues
Vol. 6, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Jean-François Allard, Alain Cornet, Christophe Debacq, Marc Meurens, Daniel Houde, and Denis Morris, "Improved detection sensitivity of D-mannitol crystalline phase content using differential spectral phase shift terahertz spectroscopy measurements," Opt. Express 19, 4644-4652 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-5-4644


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