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Optics Express

Optics Express

  • Editor: C. Martijin de Sterke
  • Vol. 19, Iss. 7 — Mar. 28, 2011
  • pp: 6131–6140

Determination of the scattering anisotropy with optical coherence tomography

V. M. Kodach, D. J. Faber, J. van Marle, T. G. van Leeuwen, and J. Kalkman  »View Author Affiliations


Optics Express, Vol. 19, Issue 7, pp. 6131-6140 (2011)
http://dx.doi.org/10.1364/OE.19.006131


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Abstract

In this work we demonstrate measurements with optical coherence tomography (OCT) of the scattering phase function in the backward direction and the scattering anisotropy parameter g. Measurements of the OCT attenuation coefficient and the backscattering amplitude are performed on calibrated polystyrene microspheres with a time-domain OCT system. From these measurements the phase function in the backward direction is determined. The measurements are described by the single scattering model and match Mie calculations very well. Measurements on Intralipid demonstrate the ability to determine the g of polydisperse samples and, for Intralipid, g = 0.35 ± 0.03 is measured, which is well in agreement with g from literature. These measurements are validated using the Intralipid particle size distribution determined from TEM measurements. Measurements of g and the scattering phase function in the backward direction can be used to monitor changes in backscattering, which can indicate morphological changes of the sample or act as contrast enhancement mechanism.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.7050) Scattering : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 19, 2011
Revised Manuscript: March 1, 2011
Manuscript Accepted: March 3, 2011
Published: March 17, 2011

Virtual Issues
Vol. 6, Iss. 4 Virtual Journal for Biomedical Optics

Citation
V. M. Kodach, D. J. Faber, J. van Marle, T. G. van Leeuwen, and J. Kalkman, "Determination of the scattering anisotropy with optical coherence tomography," Opt. Express 19, 6131-6140 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-7-6131


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References

  1. D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. G. van Leeuwen, “Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography,” Opt. Express 12(19), 4353–4365 (2004). [CrossRef] [PubMed]
  2. F. J. van der Meer, D. J. Faber, D. M. Baraznji Sassoon, M. C. Aalders, G. Pasterkamp, and T. G. van Leeuwen, “Localized measurement of optical attenuation coefficients of atherosclerotic plaque constituents by quantitative optical coherence tomography,” IEEE Trans. Med. Imaging 24(10), 1369–1376 (2005). [CrossRef] [PubMed]
  3. F. J. van der Meer, D. J. Faber, J. Perree, G. Pasterkamp, D. B. Sassoon, and T. G. van Leeuwen, "Quantitative optical coherence tomography of arterial wall components," Lasers in Medical Science 20, 45-51 (2005). [CrossRef] [PubMed]
  4. V. M. Kodach, J. Kalkman, D. J. Faber, and T. G. van Leeuwen, “Quantitative comparison of the OCT imaging depth at 1300 nm and 1600 nm,” Biomed. Opt. Express 1(1), 176–185 (2010). [CrossRef]
  5. D. Levitz, L. Thrane, M. H. Frosz, P. E. Andersen, C. B. Andersen, S. Andersson-Engels, J. Valanciunaite, J. Swartling, and P. R. Hansen, “Determination of optical scattering properties of highly-scattering media in optical coherence tomography images,” Opt. Express 12(2), 249–259 (2004). [CrossRef] [PubMed]
  6. C. Xu, J. M. Schmitt, S. G. Carlier, and R. Virmani, “Characterization of atherosclerosis plaques by measuring both backscattering and attenuation coefficients in optical coherence tomography,” J. Biomed. Opt. 13(3), 034003 (2008). [CrossRef] [PubMed]
  7. Y. Wang and R. Wang, “Autocorrelation optical coherence tomography for mapping transverse particle-flow velocity,” Opt. Lett. 35(21), 3538–3540 (2010). [CrossRef] [PubMed]
  8. J. Kalkman, R. Sprik, and T. G. van Leeuwen, “Path-length-resolved diffusive particle dynamics in spectral-domain optical coherence tomography,” Phys. Rev. Lett. 105(19), 198302 (2010). [CrossRef]
  9. J. Pyhtila, R. Graf, and A. Wax, “Determining nuclear morphology using an improved angle-resolved low coherence interferometry system,” Opt. Express 11(25), 3473–3484 (2003). [CrossRef] [PubMed]
  10. A. E. Desjardins, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Backscattering spectroscopic contrast with angle-resolved optical coherence tomography,” Opt. Lett. 32(21), 3158–3160 (2007). [CrossRef] [PubMed]
  11. J. Kalkman, A. V. Bykov, D. J. Faber, and T. G. van Leeuwen, “Multiple and dependent scattering effects in Doppler optical coherence tomography,” Opt. Express 18(4), 3883–3892 (2010). [CrossRef] [PubMed]
  12. L. Thrane, H. T. Yura, and P. E. Andersen, “Analysis of optical coherence tomography systems based on the extended Huygens-Fresnel principle,” J. Opt. Soc. Am. A 17(3), 484–490 (2000). [CrossRef]
  13. J. M. Schmitt, A. Knuttel, and R. F. Bonner, “Measurement of optical properties of biological tissues by low-coherence reflectometry,” Appl. Opt. 32(30), 6032–6042 (11993). [CrossRef]
  14. D. J. Faber and T. G. van Leeuwen, “Are quantitative attenuation measurements of blood by optical coherence tomography feasible?” Opt. Lett. 34(9), 1435–1437 (2009). [CrossRef] [PubMed]
  15. J. W. Goodman, Statistical optics (Wiley, New York, 1985).
  16. T. G. van Leeuwen, D. J. Faber, and M. C. Aalders, “Measurement of the axial point spread function in scattering media using single-mode fiber-based optical coherence tomography,” IEEE J. Sel. Top. Quantum Electron. 9(2), 227–233 (2003). [CrossRef]
  17. C. Akcay, P. Parrein, and J. P. Rolland, “Estimation of Longitudinal Resolution in Optical Coherence Imaging,” Appl. Opt. 41(25), 5256–5262 (2002). [CrossRef] [PubMed]
  18. A. Unterhuber, B. Povazay, B. Hermann, H. Sattmann, W. Drexler, V. Yakovlev, G. Tempea, C. Schubert, E. M. Anger, P. K. Ahnelt, M. Stur, J. E. Morgan, A. Cowey, G. Jung, T. Le, and A. Stingl, “Compact, low-cost Ti:Al2O3 laser for in vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett. 28(11), 905–907 (2003). [CrossRef] [PubMed]
  19. H. J. van Staveren, C. J. M. Moes, J. van Marie, S. A. Prahl, and M. J. C. van Gemert, “Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm,” Appl. Opt. 30(31), 4507–4514 (1991). [CrossRef] [PubMed]
  20. C. Chen, J. Q. Lu, H. F. Ding, K. M. Jacobs, Y. Du, and X. H. Hu, “A primary method for determination of optical parameters of turbid samples and application to intralipid between 550 and 1630 nm,” Opt. Express 14(16), 7420–7435 (2006). [CrossRef] [PubMed]
  21. J. R. Mourant, J. P. Freyer, A. H. Hielscher, A. A. Eick, D. Shen, and T. M. Johnson, “Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics,” Appl. Opt. 37(16), 3586–3593 (1998). [CrossRef]
  22. N. Bosschaart, D. J. Faber, T. G. van Leeuwen, and M. C. G. Aalders, “Measurements of wavelength dependent scattering and backscattering coefficients by low-coherence spectroscopy,” J. Biomed.Opt. 16, 030503 (2011). [PubMed]
  23. R. Michels, F. Foschum, and A. Kienle, “Optical properties of fat emulsions,” Opt. Express 16(8), 5907–5925 (2008). [CrossRef] [PubMed]
  24. B. Karamata, M. Laubscher, M. Leutenegger, S. Bourquin, T. Lasser, and P. Lambelet, “Multiple scattering in optical coherence tomography. I. Investigation and modeling,” J. Opt. Soc. Am. A 22(7), 1369–1379 (2005). [CrossRef]

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