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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 8 — Apr. 11, 2011
  • pp: 7034–7061

Optical detection of target molecule induced aggregation of nanoparticles by means of high-Q resonators

Jeremy Witzens and Michael Hochberg  »View Author Affiliations

Optics Express, Vol. 19, Issue 8, pp. 7034-7061 (2011)

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We theoretically investigate a novel scheme to detect target molecule induced, or suppressed, aggregation of nanoparticles. High-Q optical resonators are used to both optically trap gold nanoparticle clusters and to detect their presence via a shift in the resonance wavelength. The well depth of the optical trap is chosen to be relatively low compared to the thermal energy of the nanoparticles, so that trapping of single nanoparticles is marginal and results in a comparatively small wavelength shift. Aggregation of functionalized gold nanoparticles is mediated or suppressed via binding to a target molecule. The well depth for the resulting nanoparticle clusters scales much more favorably relative to Brownian motion, resulting in large nanoparticle concentration enhancements in the evanescent field region of the resonator. We predict a target molecule sensitivity in the tens of fM range. In order to predict the resonator response, a complete theory of time resolved nanoparticle cluster trapping dynamics is derived. In particular, the formalism of Kramers’ escape time is adapted to 2D (silicon wire) and 3D (ring resonator) optical traps.

© 2011 OSA

OCIS Codes
(140.7010) Lasers and laser optics : Laser trapping
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 22, 2010
Revised Manuscript: March 1, 2011
Manuscript Accepted: March 1, 2011
Published: March 29, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Jeremy Witzens and Michael Hochberg, "Optical detection of target molecule induced aggregation of nanoparticles by means of high-Q resonators," Opt. Express 19, 7034-7061 (2011)

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