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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 8 — Apr. 11, 2011
  • pp: 7299–7311

Effects of acoustic radiation force and shear waves for absorption and stiffness sensing in ultrasound modulated optical tomography

Rui Li, Daniel S. Elson, Chris Dunsby, Robert Eckersley, and Meng-Xing Tang  »View Author Affiliations

Optics Express, Vol. 19, Issue 8, pp. 7299-7311 (2011)

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Ultrasound-modulated optical tomography (UOT) combines optical contrast with ultrasound spatial resolution and has great potential for soft tissue functional imaging. One current problem with this technique is the weak optical modulation signal, primarily due to strong optical scattering in diffuse media and minimal acoustically induced modulation. The acoustic radiation force (ARF) can create large particle displacements in tissue and has been shown to be able to improve optical modulation signals. However, shear wave propagation induced by the ARF can be a significant source of nonlocal optical modulation which may reduce UOT spatial resolution and contrast. In this paper, the time evolution of shear waves was examined on tissue mimicking-phantoms exposed to 5 MHz ultrasound and 532 nm optical radiation and measured with a CCD camera. It has been demonstrated that by generating an ARF with an acoustic burst and adjusting both the timing and the exposure time of the CCD measurement, optical contrast and spatial resolution can be improved by ~110% and ~40% respectively when using the ARF rather than 5 MHz ultrasound alone. Furthermore, it has been demonstrated that this technique simultaneously detects both optical and mechanical contrast in the medium and the optical and mechanical contrast can be distinguished by adjusting the CCD exposure time.

© 2011 OSA

OCIS Codes
(170.7170) Medical optics and biotechnology : Ultrasound
(170.1065) Medical optics and biotechnology : Acousto-optics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 21, 2010
Revised Manuscript: February 14, 2011
Manuscript Accepted: February 15, 2011
Published: April 1, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Rui Li, Daniel S. Elson, Chris Dunsby, Robert Eckersley, and Meng-Xing Tang, "Effects of acoustic radiation force and shear waves for absorption and stiffness sensing in ultrasound modulated optical tomography," Opt. Express 19, 7299-7311 (2011)

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  1. M. X. Tang, D. S. Elson, R. Li, C. Dunsby, R. J. Eckersley, and P. N. T. Wells, “Photoacoustics, thermoacoustics, and acousto-optics for biomedical imaging,” Proc. Inst. Mech. Eng. H 224(2H2), 291–306 (2010). [CrossRef] [PubMed]
  2. L. V. Wang, “Ultrasound-mediated biophotonic imaging: a review of acousto-optical tomography and photo-acoustic tomography,” Dis. Markers 19(2-3), 123–138 (2003-2004).
  3. V. F. Humphrey, “Ultrasound and matter—physical interactions,” Prog. Biophys. Mol. Biol. 93(1–3), 195–211 (2007). [CrossRef]
  4. M. Fatemi and J. F. Greenleaf, “Probing the dynamics of tissue at low frequencies with the radiation force of ultrasound,” Phys. Med. Biol. 45(6), 1449–1464 (2000). [CrossRef] [PubMed]
  5. S. G. Chen, M. Fatemi, R. Kinnick, and J. F. Greenleaf, “Comparison of stress field forming methods for vibro-acoustography,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 51(3), 313–321 (2004). [CrossRef] [PubMed]
  6. R. J. Zemp, C. Kim, and L. V. Wang, “Ultrasound-modulated optical tomography with intense acoustic bursts,” Appl. Opt. 46(10), 1615–1623 (2007). [CrossRef] [PubMed]
  7. C. Kim, R. J. Zemp, and L. V. Wang, “Intense acoustic bursts as a signal-enhancement mechanism in ultrasound-modulated optical tomography,” Opt. Lett. 31(16), 2423–2425 (2006). [CrossRef] [PubMed]
  8. R. Li, L. P. Song, D. S. Elson, and M. X. Tang, “Parallel detection of amplitude-modulated, ultrasound-modulated optical signals,” Opt. Lett. 35(15), 2633–2635 (2010). [CrossRef] [PubMed]
  9. K. Daoudi, A. C. Boccara, and E. Bossy, “Detection and discrimination of optical absorption and shear stiffness at depth in tissue-mimicking phantoms by transient optoelastography,” Appl. Phys. Lett. 94(15), 154103 (2009). [CrossRef]
  10. H. J. van Staveren, C. J. M. Moes, J. van Marie, S. A. Prahl, and M. J. C. van Gemert, “Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm,” Appl. Opt. 30(31), 4507–4514 (1991). [CrossRef] [PubMed]
  11. T. J. Hall, M. Bilgen, M. F. Insana, and T. A. Krouskop, “Phantom materials for elastography,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 44(6), 1355–1365 (1997). [CrossRef]
  12. E. Bossy, A. R. Funke, K. Daoudi, A. C. Boccara, M. Tanter, and M. Fink, “Transient optoelastography in optically diffusive media,” Appl. Phys. Lett. 90(17), 174111 (2007). [CrossRef]
  13. S. J. Kirkpatrick, D. D. Duncan, and E. M. Wells-Gray, “Detrimental effects of speckle-pixel size matching in laser speckle contrast imaging,” Opt. Lett. 33(24), 2886–2888 (2008). [CrossRef] [PubMed]

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