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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 8 — Apr. 11, 2011
  • pp: 7603–7615

Ultra-slim plastic endomicroscope objective for non-linear microscopy

Matthew Kyrish, Urs Utzinger, Michael R. Descour, Brenda K. Baggett, and Tomasz S. Tkaczyk  »View Author Affiliations


Optics Express, Vol. 19, Issue 8, pp. 7603-7615 (2011)
http://dx.doi.org/10.1364/OE.19.007603


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Abstract

Non-linear microscopy has the potential to provide clinically useful information on the structure of biological tissue in vivo via an endomicroscope. The ability to use plastic as the optical material in a multiphoton objective was evaluated based on several criteria including autofluorescence, injection molding induced birefringence, and pulse broadening due to group velocity dispersion. An all-plastic, refractive ultra-slim endoscope objective was built with design specifications of NA = 0.4, FOV = 250 μm, 1.27 mm outer diameter, and 0.8 mm clear aperture. Initial images of second-harmonic generation signal (illumination at 780 nm) in collagen fibers and two-photon excited fluorescence (illumination at 920 nm) of Convallaria rhizome are reported.

© 2011 OSA

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(350.3950) Other areas of optics : Micro-optics
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 17, 2011
Revised Manuscript: March 28, 2011
Manuscript Accepted: March 29, 2011
Published: April 5, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Matthew Kyrish, Urs Utzinger, Michael R. Descour, Brenda K. Baggett, and Tomasz S. Tkaczyk, "Ultra-slim plastic endomicroscope objective for non-linear microscopy," Opt. Express 19, 7603-7615 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-8-7603


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