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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 9 — Apr. 25, 2011
  • pp: 8179–8186

Plastic lab-on-a-chip for fluorescence excitation with integrated organic semiconductor lasers

Christoph Vannahme, Sönke Klinkhammer, Uli Lemmer, and Timo Mappes  »View Author Affiliations

Optics Express, Vol. 19, Issue 9, pp. 8179-8186 (2011)

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Laser light excitation of fluorescent markers offers highly sensitive and specific analysis for bio-medical or chemical analysis. To profit from these advantages for applications in the field or at the point-of-care, a plastic lab-on-a-chip with integrated organic semiconductor lasers is presented here. First order distributed feedback lasers based on the organic semiconductor tris(8-hydroxyquinoline) aluminum (Alq3) doped with the laser dye 4-dicyanomethylene-2-methyl-6-(p-dimethylaminostyril)-4H-pyrane (DCM), deep ultraviolet induced waveguides, and a nanostructured microfluidic channel are integrated into a poly(methyl methacrylate) (PMMA) substrate. A simple and parallel fabrication process is used comprising thermal imprint, DUV exposure, evaporation of the laser material, and sealing by thermal bonding. The excitation of two fluorescent marker model systems including labeled antibodies with light emitted by integrated lasers is demonstrated.

© 2011 OSA

OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(140.3490) Lasers and laser optics : Lasers, distributed-feedback
(140.7300) Lasers and laser optics : Visible lasers
(280.3420) Remote sensing and sensors : Laser sensors

ToC Category:
Lasers and Laser Optics

Original Manuscript: January 12, 2011
Revised Manuscript: February 16, 2011
Manuscript Accepted: March 17, 2011
Published: April 14, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Christoph Vannahme, Sönke Klinkhammer, Uli Lemmer, and Timo Mappes, "Plastic lab-on-a-chip for fluorescence excitation with integrated organic semiconductor lasers," Opt. Express 19, 8179-8186 (2011)

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