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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 1 — Jan. 2, 2012
  • pp: 283–290

Non-contact time-resolved diffuse reflectance imaging at null source-detector separation

M. Mazurenka, A. Jelzow, H. Wabnitz, D. Contini, L. Spinelli, A. Pifferi, R. Cubeddu, A. Dalla Mora, A. Tosi, F. Zappa, and R. Macdonald  »View Author Affiliations


Optics Express, Vol. 20, Issue 1, pp. 283-290 (2012)
http://dx.doi.org/10.1364/OE.20.000283


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Abstract

We report results of the proof-of-principle tests of a novel non-contact tissue imaging system. The system utilizes a quasi-null source-detector separation approach for time-domain near-infrared spectroscopy, taking advantage of an innovative state-of-the-art fast-gated single photon counting detector. Measurements on phantoms demonstrate the feasibility of the non-contact approach for the detection of optically absorbing perturbations buried up to a few centimeters beneath the surface of a tissue-like turbid medium. The measured depth sensitivity and spatial resolution of the new system are close to the values predicted by Monte Carlo simulations for the inhomogeneous medium and an ideal fast-gated detector, thus proving the feasibility of the non-contact approach for high density diffuse reflectance measurements on tissue. Potential applications of the system are also discussed.

© 2011 OSA

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 13, 2011
Revised Manuscript: November 25, 2011
Manuscript Accepted: December 5, 2011
Published: December 20, 2011

Virtual Issues
Vol. 7, Iss. 3 Virtual Journal for Biomedical Optics

Citation
M. Mazurenka, A. Jelzow, H. Wabnitz, D. Contini, L. Spinelli, A. Pifferi, R. Cubeddu, A. Dalla Mora, A. Tosi, F. Zappa, and R. Macdonald, "Non-contact time-resolved diffuse reflectance imaging at null source-detector separation," Opt. Express 20, 283-290 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-1-283


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