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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 12 — Jun. 4, 2012
  • pp: 13501–13512

Femtosecond dark-field imaging with an X-ray free electron laser

A.V. Martin, N.D. Loh, C.Y. Hampton, R.G. Sierra, F. Wang, A. Aquila, S. Bajt, M. Barthelmess, C. Bostedt, J.D. Bozek, N. Coppola, S.W. Epp, B. Erk, H. Fleckenstein, L. Foucar, M. Frank, H. Graafsma, L. Gumprecht, A. Hartmann, R. Hartmann, G. Hauser, H. Hirsemann, P. Holl, S. Kassemeyer, N. Kimmel, M. Liang, L. Lomb, F.R.N.C. Maia, S. Marchesini, K. Nass, E. Pedersoli, C. Reich, D. Rolles, B. Rudek, A. Rudenko, J. Schulz, R.L. Shoeman, H. Soltau, D. Starodub, J. Steinbrener, F. Stellato, L. Strüder, J. Ullrich, G. Weidenspointner, T.A. White, C.B. Wunderer, A. Barty, I. Schlichting, M.J. Bogan, and H.N. Chapman  »View Author Affiliations


Optics Express, Vol. 20, Issue 12, pp. 13501-13512 (2012)
http://dx.doi.org/10.1364/OE.20.013501


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Abstract

The emergence of femtosecond diffractive imaging with X-ray lasers has enabled pioneering structural studies of isolated particles, such as viruses, at nanometer length scales. However, the issue of missing low frequency data significantly limits the potential of X-ray lasers to reveal sub-nanometer details of micrometer-sized samples. We have developed a new technique of dark-field coherent diffractive imaging to simultaneously overcome the missing data issue and enable us to harness the unique contrast mechanisms available in dark-field microscopy. Images of airborne particulate matter (soot) up to two microns in length were obtained using single-shot diffraction patterns obtained at the Linac Coherent Light Source, four times the size of objects previously imaged in similar experiments. This technique opens the door to femtosecond diffractive imaging of a wide range of micrometer-sized materials that exhibit irreproducible complexity down to the nanoscale, including airborne particulate matter, small cells, bacteria and gold-labeled biological samples.

© 2012 OSA

OCIS Codes
(110.7440) Imaging systems : X-ray imaging
(110.3010) Imaging systems : Image reconstruction techniques

ToC Category:
Imaging Systems

History
Original Manuscript: March 23, 2012
Revised Manuscript: April 21, 2012
Manuscript Accepted: April 22, 2012
Published: May 31, 2012

Virtual Issues
Vol. 7, Iss. 8 Virtual Journal for Biomedical Optics

Citation
A.V. Martin, N.D. Loh, C.Y. Hampton, R.G. Sierra, F. Wang, A. Aquila, S. Bajt, M. Barthelmess, C. Bostedt, J.D. Bozek, N. Coppola, S.W. Epp, B. Erk, H. Fleckenstein, L. Foucar, M. Frank, H. Graafsma, L. Gumprecht, A. Hartmann, R. Hartmann, G. Hauser, H. Hirsemann, P. Holl, S. Kassemeyer, N. Kimmel, M. Liang, L. Lomb, F.R.N.C. Maia, S. Marchesini, K. Nass, E. Pedersoli, C. Reich, D. Rolles, B. Rudek, A. Rudenko, J. Schulz, R.L. Shoeman, H. Soltau, D. Starodub, J. Steinbrener, F. Stellato, L. Strüder, J. Ullrich, G. Weidenspointner, T.A. White, C.B. Wunderer, A. Barty, I. Schlichting, M.J. Bogan, and H.N. Chapman, "Femtosecond dark-field imaging with an X-ray free electron laser," Opt. Express 20, 13501-13512 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-12-13501


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References

  1. M. M. Seibert, T. Ekeberg, F. R. N. C. Maia, M. Svenda, J. Andreasson, O. Jonsson, D. Odic, B. Iwan, A. Rocker, D. Westphal, M. Hantke, D. P. DePonte, A. Barty, J. Schulz, L. Gumprecht, N. Coppola, A. Aquila, M. Liang, T. A. White, A. Martin, C. Caleman, S. Stern, C. Abergel, V. Seltzer, J.-M. Claverie, C. Bostedt, J. D. Bozek, S. Boutet, A. A. Miahnahri, M. Messerschmidt, J. Krzywinski, G. Williams, K. O. Hodgson, M. J. Bogan, C. Y. Hampton, R. G. Sierra, D. Starodub, I. Andersson, S. Bajt, M. Barthelmess, J. C. H. Spence, P. Fromme, U. Weierstall, R. Kirian, M. Hunter, R. B. Doak, S. Marchesini, S. P. Hau-Riege, M. Frank, R. L. Shoeman, L. Lomb, S. W. Epp, R. Hartmann, D. Rolles, A. Rudenko, C. Schmidt, L. Foucar, N. Kimmel, P. Holl, B. Rudek, B. Erk, A. Homke, C. Reich, D. Pietschner, G. Weidenspointner, L. Struder, G. Hauser, H. Gorke, J. Ullrich, I. Schlichting, S. Herrmann, G. Schaller, F. Schopper, H. Soltau, K.-U. Kuhnel, R. Andritschke, C.-D. Schroter, F. Krasniqi, M. Bott, S. Schorb, D. Rupp, M. Adolph, T. Gorkhover, H. Hirsemann, G. Potdevin, H. Graafsma, B. Nilsson, H. N. Chapman, and J. Hajdu, “Single mimivirus particles intercepted and imaged with an x-ray laser,” Nature470, 79–81 (2011). [CrossRef]
  2. A. V. Martin, J. Andreassonn, A. Aquila, S. Bajt, T. R. Barends, M. Barthelmess, A. Barty, W. H. Benner, C. Bostedt, J. D. Bozek, P. Bucksbaum, C. Caleman, N. Coppola, D. P. DePonte, T. Ekeberg, S. W. Epp, B. Erk, G. R. Farquar, H. Fleckenstein, L. Foucar, M. Frank, L. Gumprecht, C. Y. Hampton, M. Hantke, A. Hartmann, E. Hartmann, R. Hartmann, S. P. Hau-Riege, G. Hauser, P. Holl, A. Hoemke, O. Jonssonn, S. Kassemeyer, N. Kimmel, M. Kiskinovak, F. Krasniqi, J. Krzywinski, M. Liang, N.-T. D. Loh, L. Lomb, F. R. N. C. Maia, S. Marchesini, M. Messerschmidt, K. Nass, D. Odic, E. Pedersoli, C. Reich, D. Rolles, B. Rudek, A. Rudenko, C. Schmidt, J. Schulz, M. M. Seibert, R. L. Shoeman, R. G. Sierra, H. Soltau, D. Starodub, J. Steinbrener, F. Stellato, L. Struder, M. Svenda, H. Tobias, J. Ullrich, G. Weidenspointner, D. Westphal, T. A. White, G. Williams, J. Hajdu, I. Schlichting, M. J. Bogan, and H. N. Chapman, “Single particle imaging with soft x-rays at the linac coherent light source,” Proc. SPIE8078, 807809 (2011). [CrossRef]
  3. N. D. Loh, C. Y. Hampton, A. V. Martin, D. Starodub, R. G. Sierra, A. Barty, A. Aquila, J. Schulz, L. Lomb, J. Steinbrener, S. Shoeman, R. L. Kassemeyer, C. Bostedt, J. Bozek, S. W. Epp, B. Erk, R. Hartmann, D. Rolles, A. Rudenko, B. Rudek, L. Foucar, N. Kimmel, G. Weidenspointner, G. Hauser, P. Holl, E. Pedersoli, M. Liang, M. Hunter, L. Gumprecht, N. Coppola, C. Wunderer, H. Graafsma, F. R. N. C. Maia, T. Ekeberg, M. Hantke, H. Fleckenstein, H. Hirsemann, K. Nass, T. A. White, H. J. Tobias, G. R. Farquar, W. H. Benner, S. Hau-Riege, C. Reich, A. Hartmann, H. Soltau, S. Marchesini, S. Bajt, M. Barthelmess, P. Bucksbaum, K. O. Hodgson, L. Strüder, J. Ullrich, M. Frank, I. Schlichting, H. N. Chapman, and M. J. Bogan, “Fractal morphology, imaging and mass spectrometry of single aerosol particles in flight,” Nature (2012). (submitted). [PubMed]
  4. G. J. Williams, M. A. Pfeifer, I. A. Vartanyants, and I. K. Robinson, “Three-dimensional imaging of microstructure in Au nanocrystals,” Phys. Rev. Lett.90, 175501 (2003). [CrossRef] [PubMed]
  5. M. A. Pfeifer, G. J. Williams, I. A. Vartanyants, R. Harder, and I. K. Robinson, “Three-dimensional mapping of a deformation field inside a nanocrystal,” Nature442, 63–66 (2006). [CrossRef] [PubMed]
  6. J. Miao, K. O. Hodgson, T. Ishikawa, C. A. Larabell, M. A. LeGros, and Y. Nishino, “Imaging whole Escherichia coli bacteria by using single-particle X-ray diffraction,” Proc. Natl. Acad. Sci. USA100, 110–112 (2003). [CrossRef] [PubMed]
  7. D. Shapiro, P. Thibault, T. Beetz, V. Elser, M. Howells, C. Jacobsen, J. Kirz, E. Lima, H. Miao, A. M. Neiman, and D. Sayre, “Biological imaging by soft X-ray diffraction microscopy,” Proc. Natl. Acad. Sci. USA102, 15343–15346 (2005). [CrossRef] [PubMed]
  8. P. Thibault, P. Elser, C. Jacobsen, D. Shapiro, and D. Sayre, “Reconstruction of a yeast cell from x-ray diffraction data,” Acta Crystallogr.A62, 248–261 (2006).
  9. L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, x-ray pnccds combined with electron and ion imaging spectrometers in a multi purpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Meth. A614, 483–496 (2009). [CrossRef]
  10. XCAM Limited, UK. http://www.xcam.co.uk/documents/XCM_AP_237_1.pdf .
  11. H. Philipp, M. Hromalik, M. Tate, L. Koerner, and S. Gruner, “Pixel array detector for x-ray free electron laser experiments.” Nucl. Instrum. Meth. A649, 67–69 (2011). [CrossRef]
  12. F. Ottensmeyer, “Macromolecular finestructure by dark field electron microscopy,” Biophys. J.9, 1144–1149 (1969). [CrossRef] [PubMed]
  13. F. Ottensmeyer, “Scattered electrons in microscopy and microanalysis,” Science215, 461–466 (1982). [CrossRef] [PubMed]
  14. G. Jamjoom, “Dark-field microscopy for detection of malaria in unstained blood films,” J. Clin. Microbiol.17, 717–721 (1983). [PubMed]
  15. A. V. Crewe, J. Wall, and J. Langmore, “Visibility of single atoms,” Science168, 1338–1340 (1970). [CrossRef] [PubMed]
  16. J. M. LeBeau, S. D. Findlay, L. J. Allen, and S. Stemmer, “Quantitative atomic resolution scanning transmission electron microscopy,” Phys. Rev. Lett.100, 206101 (2008). [CrossRef] [PubMed]
  17. J. Buban, Q. Ramasse, B. Gipson, N. Browning, and H. Strahlberg, “High-resolution low-dose scanning transmission electron microscopy,” J. Electron Microsc.59, 103–112 (2010). [CrossRef]
  18. G. R. Morrison and M. T. Browne, “Dark-field imaging with the scanning transmission x-ray microscope,” Rev. Sci. Instrum.63, 611–614 (1992). [CrossRef]
  19. H. Chapman, C. Jacobsen, and S. Williams, “A characterisation of dark-field imaging of colloidal gold labels in a scanning transmission x-ray microscope,” Ultramicroscopy62, 191–213 (1996). [CrossRef] [PubMed]
  20. J. C. H. Spence, High-resolution Electron Microscopy (Oxford University Press, 2003).
  21. J. Miao, J. E. Amonette, Y. Nishino, T. Ishikawa, and K. O. Hodgson, “Direct determination of the absolute electron density of nanostructured and disordered materials at sub-10-nm resolution” Phys. Rev. B68, 012201 (2003). [CrossRef]
  22. X. Huang, J. Nelson, J. Steinbrener, J. Kirz, J. Turner, and C. Jacobsen, “Incorrect support and missing center tolerances of phasing algorithms.” Opt. Express18, 26441–26449 (2010). [CrossRef] [PubMed]
  23. S. Marchesini, H. He, H. N. Chapman, S. P. Hau-Riege, A. Noy, M. R. Howells, U. Weierstall, and J. C. H. Spence, “X-ray image reconstruction from a diffraction pattern alone,” Phys. Rev. B68, 140101 (2003). [CrossRef]
  24. J. R. Fienup, “Phase retrieval algorithms - a comparison,” Appl. Opt.21, 2758–2769 (1982). [CrossRef] [PubMed]
  25. C. Jacobsen, J. Kirz, and S. Williams, “Resolution in soft x-ray microscopes.” Ultramicroscopy47, 55–79 (1992). [CrossRef]
  26. R. K. Chakrabarty, H. M. Moosmüller, W. P. Arnott, M. A. Garro, and J. Walker, “Structural and fractal properties of particles emitted from spark ignition engines.” Environ. Sci. Technol.40, 6647–6654 (2006). [CrossRef] [PubMed]
  27. T. C. Bond and R. W. Bergstrom, “Light absorption by carbonaceous particles: An investigative review,” Aerosol Sci. Tech.40, 27–67 (2006). [CrossRef]
  28. M. J. Bogan, D. Starodub, C. Y. Hampton, and R. G. Sierra, “Single-particle coherent diffractive imaging with a soft x-ray free electron laser: towards soot aerosol morphology,” J. Phys. B: At. Mol. Opt. Phys.43, 194013 (2010).
  29. A. V. Martin, F. Wang, N. D. Loh, T. Ekeberg, F. R. N. C. Maia, M. Hantke, G. van der Schot, C. Y. Hampton, R. G. Sierra, A. Aquila, S. Bajt, M. Barthelmess, C. Bostedt, J. D. Bozek, N. Coppola, S. W. Epp, B. Erk, G. R. Farquar, H. Fleckenstein, L. Foucar, M. Frank, L. Gumprecht, A. Hartmann, R. Hartmann, G. Hauser, P. Holl, S. Kassemeyer, N. Kimmel, M. Liang, L. Lomb, S. Marchesini, K. Nass, E. Pedersoli, C. Reich, D. Rolles, B. Rudek, A. Rudenko, J. Schulz, R. L. Shoeman, H. Soltau, D. Starodub, J. Steinbrener, F. Stellato, L. Strüder, J. Ullrich, G. Weidenspointner, T. A. White, C. Wunderer, A. Barty, I. Schlichting, M. J. Bogan, and H. N. Chapman, “Noise-robust coherent diffractive imaging with a single diffraction pattern,” Opt. Express (2012). (submitted). [PubMed]

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