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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 13 — Jun. 18, 2012
  • pp: 14117–14129

Correcting photoacoustic signals for fluence variations using acousto-optic modulation

K. Daoudi, A. Hussain, E. Hondebrink, and W. Steenbergen  »View Author Affiliations

Optics Express, Vol. 20, Issue 13, pp. 14117-14129 (2012)

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We present a theoretical concept which may lead to quantitative photoacoustic mapping of chromophore concentrations. The approach supposes a technique capable of tagging light in a well-defined tagging volume at a specific location deep in the medium. We derive a formula that expresses the local absorption coefficient inside a medium in terms of noninvasively measured quantities and experimental parameters and we validate the theory using Monte Carlo simulations. Furthermore, we performed an experiment to basically validate the concept as a strategy to correct for fluence variations in photoacoustics. In the experiment we exploit the possibility of acousto-optic modulation, using focused ultrasound, to tag photons. Results show that the variation in photoacoustic signals of absorbing insertions embedded at different depths in a phantom, caused by fluence variations of more than one order of magnitude, can be corrected for to an accuracy of 5%.

© 2012 OSA

OCIS Codes
(170.1065) Medical optics and biotechnology : Acousto-optics
(110.5125) Imaging systems : Photoacoustics
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 12, 2012
Revised Manuscript: June 1, 2012
Manuscript Accepted: June 3, 2012
Published: June 11, 2012

Virtual Issues
Vol. 7, Iss. 8 Virtual Journal for Biomedical Optics

K. Daoudi, A. Hussain, E. Hondebrink, and W. Steenbergen, "Correcting photoacoustic signals for fluence variations using acousto-optic modulation," Opt. Express 20, 14117-14129 (2012)

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