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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 18 — Aug. 27, 2012
  • pp: 19643–19657

A fiber optic probe design to measure depth- limited optical properties in-vivo with Low-coherence Enhanced Backscattering (LEBS) Spectroscopy

Nikhil N. Mutyal, Andrew Radosevich, Bradley Gould, Jeremy D. Rogers, Andrew Gomes, Vladimir Turzhitsky, and Vadim Backman  »View Author Affiliations

Optics Express, Vol. 20, Issue 18, pp. 19643-19657 (2012)

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Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about scattering phase function is preserved. Our group has shown the ability to measure the spatial backscattering impulse response function along with depth-selective optical properties in tissue ex-vivo using LEBS. Here we report the design and implementation of a lens-free fiber optic LEBS probe capable of providing depth-limited measurements of the reduced scattering coefficient in-vivo. Experimental measurements combined with Monte Carlo simulation of scattering phantoms consisting of polystyrene microspheres in water are used to validate the performance of the probe. Additionally, depth-limited capabilities are demonstrated using Monte Carlo modeling and experimental measurements from a two-layered phantom.

© 2012 OSA

OCIS Codes
(060.2310) Fiber optics and optical communications : Fiber optics
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.1350) Scattering : Backscattering

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 6, 2012
Revised Manuscript: August 3, 2012
Manuscript Accepted: August 6, 2012
Published: August 13, 2012

Virtual Issues
Vol. 7, Iss. 10 Virtual Journal for Biomedical Optics

Nikhil N. Mutyal, Andrew Radosevich, Bradley Gould, Jeremy D. Rogers, Andrew Gomes, Vladimir Turzhitsky, and Vadim Backman, "A fiber optic probe design to measure depth- limited optical properties in-vivo with Low-coherence Enhanced Backscattering (LEBS) Spectroscopy," Opt. Express 20, 19643-19657 (2012)

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