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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 20 — Sep. 24, 2012
  • pp: 22262–22277

Dynamic light scattering optical coherence tomography

Jonghwan Lee, Weicheng Wu, James Y. Jiang, Bo Zhu, and David A. Boas  »View Author Affiliations


Optics Express, Vol. 20, Issue 20, pp. 22262-22277 (2012)
http://dx.doi.org/10.1364/OE.20.022262


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Abstract

We introduce an integration of dynamic light scattering (DLS) and optical coherence tomography (OCT) for high-resolution 3D imaging of heterogeneous diffusion and flow. DLS analyzes fluctuations in light scattered by particles to measure diffusion or flow of the particles, and OCT uses coherence gating to collect light only scattered from a small volume for high-resolution structural imaging. Therefore, the integration of DLS and OCT enables high-resolution 3D imaging of diffusion and flow. We derived a theory under the assumption that static and moving particles are mixed within the OCT resolution volume and the moving particles can exhibit either diffusive or translational motion. Based on this theory, we developed a fitting algorithm to estimate dynamic parameters including the axial and transverse velocities and the diffusion coefficient. We validated DLS-OCT measurements of diffusion and flow through numerical simulations and phantom experiments. As an example application, we performed DLS-OCT imaging of the living animal brain, resulting in 3D maps of the absolute and axial velocities, the diffusion coefficient, and the coefficient of determination.

© 2012 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(180.6900) Microscopy : Three-dimensional microscopy
(110.4153) Imaging systems : Motion estimation and optical flow

ToC Category:
Imaging Systems

History
Original Manuscript: June 15, 2012
Revised Manuscript: August 18, 2012
Manuscript Accepted: August 24, 2012
Published: September 13, 2012

Virtual Issues
Vol. 7, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Jonghwan Lee, Weicheng Wu, James Y. Jiang, Bo Zhu, and David A. Boas, "Dynamic light scattering optical coherence tomography," Opt. Express 20, 22262-22277 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-20-22262


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