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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 21 — Oct. 8, 2012
  • pp: 23944–23953

Optics InfoBase > Optics Express > Volume 20 > Issue 21 > Page 23944

A 2.5-mm diameter probe for photoacoustic and ultrasonic endoscopy

Joon-Mo Yang, Ruimin Chen, Christopher Favazza, Junjie Yao, Chiye Li, Zhilin Hu, Qifa Zhou, K. Kirk Shung, and Lihong V. Wang  »View Author Affiliations


Optics Express, Vol. 20, Issue 21, pp. 23944-23953 (2012)
http://dx.doi.org/10.1364/OE.20.023944


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Abstract

We have created a 2.5-mm outer diameter integrated photo-acoustic and ultrasonic mini-probe which can be inserted into a standard video endoscope’s instrument channel. A small-diameter focused ultrasonic transducer made of PMN-PT provides adequate signal sensitivity, and enables miniaturization of the probe. Additionally, this new endoscopic probe utilizes the same scanning mirror and micromotor-based built-in actuator described in our previous reports; however, the length of the rigid distal section of the new probe has been further reduced to ~35 mm. This paper describes the technical details of the mini-probe and presents experimental results that both quantify the imaging performance and demonstrate its in vivo imaging capability, which suggests that it could work as a mini-probe for certain clinical applications.

© 2012 OSA

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 2, 2012
Revised Manuscript: September 15, 2012
Manuscript Accepted: September 18, 2012
Published: October 4, 2012

Citation
Joon-Mo Yang, Ruimin Chen, Christopher Favazza, Junjie Yao, Chiye Li, Zhilin Hu, Qifa Zhou, K. Kirk Shung, and Lihong V. Wang, "A 2.5-mm diameter probe for photoacoustic and ultrasonic endoscopy," Opt. Express 20, 23944-23953 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-21-23944


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References

  1. L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys.35(12), 5758–5767 (2008). [CrossRef] [PubMed]
  2. J. M. Yang, K. Maslov, H. C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett.34(10), 1591–1593 (2009). [CrossRef] [PubMed]
  3. A. A. Oraevsky and A. A. Karabutov, “Optoacoustic Tomography,” in Biomedical Photonics Handbook, T. Vo-Dinh, ed. (CRC Press, 2003).
  4. L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009). [CrossRef] [PubMed]
  5. C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol.54(19), R59–R97 (2009). [CrossRef] [PubMed]
  6. P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011). [CrossRef] [PubMed]
  7. L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012). [CrossRef] [PubMed]
  8. Z. Guo, S. Hu, and L. V. Wang, “Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue,” Opt. Lett.35(12), 2067–2069 (2010). [CrossRef] [PubMed]
  9. C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011). [CrossRef] [PubMed]
  10. A. Danielli, C. P. Favazza, K. Maslov, and L. V. Wang, “Single-wavelength functional photoacoustic microscopy in biological tissue,” Opt. Lett.36(5), 769–771 (2011). [CrossRef] [PubMed]
  11. Y. Wang, S. Hu, K. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure,” Opt. Lett.36(7), 1029–1031 (2011). [CrossRef] [PubMed]
  12. S. Hu, K. Maslov, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Opt. Lett.36(7), 1134–1136 (2011). [CrossRef] [PubMed]
  13. J. Yao, K. I. Maslov, Y. Shi, L. A. Taber, and L. V. Wang, “In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth,” Opt. Lett.35(9), 1419–1421 (2010). [CrossRef] [PubMed]
  14. J. Yao, K. I. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “Label-free oxygen-metabolic photoacoustic microscopy in vivo,” J. Biomed. Opt.16(7), 076003 (2011). [CrossRef] [PubMed]
  15. M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt.14(5), 054024 (2009). [CrossRef] [PubMed]
  16. M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011). [CrossRef] [PubMed]
  17. S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt.15(1), 011101 (2010). [CrossRef] [PubMed]
  18. B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010). [CrossRef] [PubMed]
  19. J. L. Su, B. Wang, and S. Y. Emelianov, “Photoacoustic imaging of coronary artery stents,” Opt. Express17(22), 19894–19901 (2009). [CrossRef] [PubMed]
  20. A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum.81(1), 014901 (2010). [CrossRef] [PubMed]
  21. K. Jansen, A. F. van der Steen, H. M. van Beusekom, J. W. Oosterhuis, and G. van Soest, “Intravascular photoacoustic imaging of human coronary atherosclerosis,” Opt. Lett.36(5), 597–599 (2011). [CrossRef] [PubMed]
  22. E. Z. Zhang and P. C. Beard, “A miniature all-optical photoacoustic imaging probe,” Proc. SPIE7899, 78991F, 78991F-6 (2011). [CrossRef]
  23. B. Y. Hsieh, S. L. Chen, T. Ling, L. J. Guo, and P. C. Li, “All-optical scanhead for ultrasound and photoacoustic dual-modality imaging,” Opt. Express20(2), 1588–1596 (2012). [CrossRef] [PubMed]
  24. B. Wang, A. Karpiouk, D. Yeager, J. Amirian, S. Litovsky, R. Smalling, and S. Emelianov, “Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood,” Opt. Lett.37(7), 1244–1246 (2012). [CrossRef] [PubMed]
  25. T. J. Allen, A. Hall, A. P. Dhillon, J. S. Owen, and P. C. Beard, “Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range,” J. Biomed. Opt.17(6), 061209 (2012). [CrossRef] [PubMed]
  26. Y. Yuan, S. Yang, and D. Xing, “Preclinical photoacoustic imaging endoscope based on acousto-optic coaxial system using ring transducer array,” Opt. Lett.35(13), 2266–2268 (2010). [CrossRef] [PubMed]
  27. J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011). [CrossRef]
  28. M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010). [CrossRef] [PubMed]
  29. X. Wang, W. W. Roberts, P. L. Carson, D. P. Wood, and J. B. Fowlkes, “Photoacoustic tomography: a potential new tool for prostate cancer,” Biomed. Opt. Express1(4), 1117–1126 (2010). [CrossRef] [PubMed]
  30. C. Sheaff and S. Ashkenazi, “A fiber optic optoacoustic ultrasound sensor for photoacoustic endoscopy,” in Proceedings of IEEE International Ultrasonics Symposium (Institute of Electrical and Electronics Engineers, San Diego, 2010), pp. 2135–2138.
  31. Y. Yang, X. Li, T. Wang, P. D. Kumavor, A. Aguirre, K. K. Shung, Q. Zhou, M. Sanders, M. Brewer, and Q. Zhu, “Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization,” Biomed. Opt. Express2(9), 2551–2561 (2011). [CrossRef] [PubMed]
  32. C. Dietrich, ed., Endoscopic Ultrasound: An Introductory Manual and Atlas (Thieme, New York, 2006).
  33. J. Menzel and W. Domschke, “Gastrointestinal miniprobe sonography: the current status,” Am. J. Gastroenterol.95(3), 605–616 (2000). [CrossRef] [PubMed]
  34. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997). [CrossRef] [PubMed]
  35. X. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, “Imaging needle for optical coherence tomography,” Opt. Lett.25(20), 1520–1522 (2000). [CrossRef] [PubMed]
  36. X. Liu, M. J. Cobb, Y. Chen, M. B. Kimmey, and X. Li, “Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography,” Opt. Lett.29(15), 1763–1765 (2004). [CrossRef] [PubMed]
  37. S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007). [CrossRef] [PubMed]
  38. D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007). [CrossRef]
  39. H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011). [CrossRef] [PubMed]
  40. A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011). [CrossRef] [PubMed]
  41. R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004). [CrossRef] [PubMed]
  42. P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010). [CrossRef] [PubMed]
  43. L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010). [CrossRef] [PubMed]
  44. N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011). [CrossRef] [PubMed]
  45. J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012). [CrossRef] [PubMed]
  46. Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007). [CrossRef] [PubMed]
  47. Laser Institute of America, American National Standard for Safe Use of Lasers, ANSI Z136.1–2007 (American National Standards Institute, Inc., New York, NY, 2007).

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