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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 22 — Oct. 22, 2012
  • pp: 25044–25057

Non-invasive carotid imaging using optoacoustic tomography

Alexander Dima and Vasilis Ntziachristos  »View Author Affiliations


Optics Express, Vol. 20, Issue 22, pp. 25044-25057 (2012)
http://dx.doi.org/10.1364/OE.20.025044


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Abstract

The high prevalence of atherosclerosis and the corresponding derived morbidity drives the investigation of novel imaging tools for disease diagnosis and assessment. Multi-spectral optoacoustic tomography (MSOT) can resolve structural, hemodynamic and molecular parameters that relate to cardiovascular disease. Similarly to ultrasound imaging, optoacoustic (photoacoustic) imaging can be implemented as a handheld arrangement which further brings dissemination potential to point of care applications. Correspondingly, we experimentally investigate herein the performance of non-invasive optoacoustic scanning developed for carotid imaging, in phantoms and humans. The results demonstrate that traditional transducers employed in ultrasound imaging do not offer optimal MSOT imaging. Instead, feasibility to detect human carotids and carotid-sized vessels in clinically-relevant depths is better demonstrated with curved arrays and tomographic approaches.

© 2012 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1610) Medical optics and biotechnology : Clinical applications
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 13, 2012
Revised Manuscript: July 30, 2012
Manuscript Accepted: July 30, 2012
Published: October 18, 2012

Citation
Alexander Dima and Vasilis Ntziachristos, "Non-invasive carotid imaging using optoacoustic tomography," Opt. Express 20, 25044-25057 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-22-25044


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