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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 24 — Nov. 19, 2012
  • pp: 26117–26126

Optical needle endoscope for safe and precise stereotactically guided biopsy sampling in neurosurgery

Werner Göbel, David Brucker, Yvonne Kienast, Ann Johansson, Gesa Kniebühler, Adrian Rühm, Sabina Eigenbrod, Stefan Fischer, Marcus Goetz, Friedrich-Wilhelm Kreth, André Ehrhardt, Herbert Stepp, Klaus-Martin Irion, and Jochen Herms  »View Author Affiliations

Optics Express, Vol. 20, Issue 24, pp. 26117-26126 (2012)

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Proper treatment of deep seated brain tumors requires correct histological diagnosis which unambiguously necessitates biopsy sampling. Stereotactically guided sampling of biopsies is widely used but bears the danger of incorrect sampling locations and damage to intracerebral blood vessels. Here, we present a minimally invasive contact endoscopic probe that can be inserted into the tissue inside a standard biopsy needle and allows for fluorescence detection of both tumorous tissue and intracerebral blood vessels. Outer diameter of our contact probe is smaller than 1.5 mm, field-of-view in the range of several hundred microns; the optical design allows for simultaneous detection and visualization of tissue autofluorescence and selective fluorescence signals from deep seated brain tumors and vasculature as shown on in vivo animal models. We demonstrate the tumor detection capability during stereotactic needle insertion in a clinical pilot trial. Using our probe, we expect stereotactic interventions to become safer and more precise and the technology might ultimately be used also for various other kinds of applications.

© 2012 OSA

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 13, 2012
Revised Manuscript: October 23, 2012
Manuscript Accepted: October 24, 2012
Published: November 5, 2012

Virtual Issues
Vol. 7, Iss. 12 Virtual Journal for Biomedical Optics

Werner Göbel, David Brucker, Yvonne Kienast, Ann Johansson, Gesa Kniebühler, Adrian Rühm, Sabina Eigenbrod, Stefan Fischer, Marcus Goetz, Friedrich-Wilhelm Kreth, André Ehrhardt, Herbert Stepp, Klaus-Martin Irion, and Jochen Herms, "Optical needle endoscope for safe and precise stereotactically guided biopsy sampling in neurosurgery," Opt. Express 20, 26117-26126 (2012)

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