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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 24 — Nov. 19, 2012
  • pp: 26147–26159

Periodic plasmonic enhancing epitopes on a whispering gallery mode biosensor

Stephen Arnold, Venkata Ramanaiah Dantham, Curtis Barbre, Bruce A. Garetz, and Xudong Fan  »View Author Affiliations


Optics Express, Vol. 20, Issue 24, pp. 26147-26159 (2012)
http://dx.doi.org/10.1364/OE.20.026147


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Abstract

We propose the attachment of a periodic array of gold nanoparticles (epitopes) to the equator of a Whispering Gallery Mode Biosensor for the purpose of plasmonically enhancing nanoparticle sensing in a self-referencing manner while increasing the capture rate of analyte to antibodies attached to these plasmonic epitopes. Our approach can be applied to a variety of whispering gallery mode resonators from silicon/silica rings and disks to capillaries. The interpretation of the signals is particularly simple since the optical phase difference between the epitopes is designed to be an integer multiple of π, allowing the wavelength shift from each binding event to add independently.

© 2012 OSA

OCIS Codes
(230.5750) Optical devices : Resonators
(240.6680) Optics at surfaces : Surface plasmons
(260.5740) Physical optics : Resonance
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(140.3945) Lasers and laser optics : Microcavities

ToC Category:
Sensors

History
Original Manuscript: August 31, 2012
Revised Manuscript: October 25, 2012
Manuscript Accepted: October 31, 2012
Published: November 5, 2012

Virtual Issues
Vol. 7, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Stephen Arnold, Venkata Ramanaiah Dantham, Curtis Barbre, Bruce A. Garetz, and Xudong Fan, "Periodic plasmonic enhancing epitopes on a whispering gallery mode biosensor," Opt. Express 20, 26147-26159 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-24-26147


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