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Simultaneous retrieval of fluidic refractive index and surface adsorbed molecular film thickness using silicon wire waveguide biosensorsYuki Atsumi, Dan-Xia Xu, André Delâge, Jens H. Schmid, Martin Vachon, Pavel Cheben, Siegfried Janz, Nobuhiko Nishiyama, and Shigehisa Arai »View Author Affiliations
Yuki Atsumi,1,2
Dan-Xia Xu,1,*
André Delâge,1
Jens H. Schmid,1,2
Martin Vachon,1
Pavel Cheben,1
Siegfried Janz,1
Nobuhiko Nishiyama,2
and Shigehisa Arai2,3
1National Research Council Canada,1200 Montreal Rd, Ottawa, ON, K1A 0R6, Canada 2Department of Electrical and Electronic Engineering, Tokyo Institute of Technology, 2-12-1-S3-12 O-okayama, Meguro-ku, Tokyo 152-8550, Japan 3Quantum Nanoelectronics Research Center, Tokyo Institute of Technology, 2-12-1-S9-5 O-okayama, Meguro-ku, Tokyo 152-8552, Japan *Corresponding author: Danxia.Xu@nrc-cnrc.gc.ca |
Optics Express, Vol. 20, Issue 24, pp. 26969-26977 (2012)
http://dx.doi.org/10.1364/OE.20.026969
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Abstract
For silicon wire based ring resonator biosensors, we investigate the simultaneous retrieval of changes in the fluidic refractive index ∆nc and surface adsorbed molecular film thickness ∆dF. This can be achieved by monitoring the resonance shifts of the sensors operating in the TE and TM polarizations at the same time. Although this procedure is straightforward in principle, significant retrieval errors can be introduced due to deviations in the sensor waveguide cross-sections from their nominal values in the range commonly encountered for silicon photonic wire devices. We propose a method of determining the fabricated waveguide size using the group indices derived from measured free spectral range (FSR) of the resonators. We further demonstrate that using experimentally measured group index values, the waveguide size can be determined to accuracies of ± 2 nm in width and ± 1 nm in height. By using this procedure, ∆nc and ∆dF can be obtained to a precision of within 10% of the true values using optically measurable parameters, improving the retrieval accuracy by more than 3 times.
© 2012 OSA
OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(130.6010) Integrated optics : Sensors
(230.5750) Optical devices : Resonators
ToC Category:
Integrated Optics
History
Original Manuscript: September 18, 2012
Revised Manuscript: November 6, 2012
Manuscript Accepted: November 6, 2012
Published: November 15, 2012
Virtual Issues
Vol. 7, Iss. 12 Virtual Journal for Biomedical Optics
Citation
Yuki Atsumi, Dan-Xia Xu, André Delâge, Jens H. Schmid, Martin Vachon, Pavel Cheben, Siegfried Janz, Nobuhiko Nishiyama, and Shigehisa Arai, "Simultaneous retrieval of fluidic refractive index and surface adsorbed molecular film thickness using silicon wire waveguide biosensors," Opt. Express 20, 26969-26977 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-24-26969
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References
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- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
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- D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express16(19), 15137–15148 (2008). [CrossRef] [PubMed]
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- W. Bogaerts, P. De Heyn, T. Van Vaerenbergh, K. De Vos, S. Kumar Selvaraja, T. Claes, P. Dumon, P. Bienstman, D. Van Thourhout, and R. Baets, “Silicon microring resonators,” Laser Photonics Rev.6(1), 47–73 (2012). [CrossRef]
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- X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta620(1-2), 8–26 (2008). [CrossRef] [PubMed]
- D.-X. Xu, M. Vachon, A. Densmore, R. Ma, S. Janz, A. Delâge, J. Lapointe, P. Cheben, J. H. Schmid, E. Post, S. Messaoudène, and J.-M. Fédéli, “Real-time cancellation of temperature induced resonance shifts in SOI wire waveguide ring resonator label-free biosensor arrays,” Opt. Express18(22), 22867–22879 (2010). [CrossRef] [PubMed]
- M. Iqbal, M. A. Gleeson, B. Spaugh, F. Tybor, W. G. Gunn, M. Hochberg, T. Baehr-Jones, R. C. Bailey, and L. C. Gunn, “Label-free biosensor arrays based on silicon ring resonators and high-speed optical scanning instrumentation,” IEEE J. Sel. Top. Quantum Electron.16(3), 654–661 (2010). [CrossRef]
- D. R. Shankaran, K. V. Gobi, and N. Miura, “Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical, food and environmental interest,” Sens. Actuators B Chem.121(1), 158–177 (2007). [CrossRef]
- M. Iqbal, M. A. Gleeson, B. Spaugh, F. Tybor, W. G. Gunn, M. Hochberg, T. Baehr-Jones, R. C. Bailey, and L. C. Gunn, “Label-free biosensor arrays based on silicon ring resonators and high-speed optical scanning instrumentation,” IEEE J. Sel. Top. Quantum Electron.16(3), 654–661 (2010). [CrossRef]
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- D.-X. Xu, A. Delâge, J. H. Schmid, R. Ma, S. Wang, J. Lapointe, M. Vachon, P. Cheben, and S. Janz, “Selecting the polarization in silicon photonic wire components,” Proc. SPIE8266, 82660G, 82660G-9 (2012). [CrossRef]
- D.-X. Xu, M. Vachon, A. Densmore, R. Ma, S. Janz, A. Delâge, J. Lapointe, P. Cheben, J. H. Schmid, E. Post, S. Messaoudène, and J.-M. Fédéli, “Real-time cancellation of temperature induced resonance shifts in SOI wire waveguide ring resonator label-free biosensor arrays,” Opt. Express18(22), 22867–22879 (2010). [CrossRef] [PubMed]
- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
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- D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express16(19), 15137–15148 (2008). [CrossRef] [PubMed]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- W. Bogaerts, P. De Heyn, T. Van Vaerenbergh, K. De Vos, S. Kumar Selvaraja, T. Claes, P. Dumon, P. Bienstman, D. Van Thourhout, and R. Baets, “Silicon microring resonators,” Laser Photonics Rev.6(1), 47–73 (2012). [CrossRef]
- D.-X. Xu, A. Delâge, J. H. Schmid, R. Ma, S. Wang, J. Lapointe, M. Vachon, P. Cheben, and S. Janz, “Selecting the polarization in silicon photonic wire components,” Proc. SPIE8266, 82660G, 82660G-9 (2012). [CrossRef]
- D.-X. Xu, M. Vachon, A. Densmore, R. Ma, S. Janz, A. Delâge, J. Lapointe, P. Cheben, J. H. Schmid, E. Post, S. Messaoudène, and J.-M. Fédéli, “Real-time cancellation of temperature induced resonance shifts in SOI wire waveguide ring resonator label-free biosensor arrays,” Opt. Express18(22), 22867–22879 (2010). [CrossRef] [PubMed]
- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
- A. Delâge, D.-X. Xu, R. W. McKinnon, E. Post, P. Waldron, J. Lapointe, C. Storey, A. Densmore, S. Janz, B. Lamontagne, P. Cheben, and J. H. Schmid, “Wavelength-dependent model of a ring resonator sensor excited by a directional coupler,” J. Lightwave Technol.27(9), 1172–1180 (2009). [CrossRef]
- D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express16(19), 15137–15148 (2008). [CrossRef] [PubMed]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
- D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express16(19), 15137–15148 (2008). [CrossRef] [PubMed]
- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
- W. Lukosz, “Priciples and sensitivities of integrated optical and surface plasmon sensors for direct affinity sensing and immunosensing,” Biosens. Bioelectron.6(3), 215–225 (1991). [CrossRef]
- K. Tiefenthaler and W. Lukosz, “Sensitivity of grating couplers as integrated-optical chemical sensors,” J. Opt. Soc. Am. B6(2), 209–220 (1989). [CrossRef]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- D.-X. Xu, A. Delâge, J. H. Schmid, R. Ma, S. Wang, J. Lapointe, M. Vachon, P. Cheben, and S. Janz, “Selecting the polarization in silicon photonic wire components,” Proc. SPIE8266, 82660G, 82660G-9 (2012). [CrossRef]
- D.-X. Xu, M. Vachon, A. Densmore, R. Ma, S. Janz, A. Delâge, J. Lapointe, P. Cheben, J. H. Schmid, E. Post, S. Messaoudène, and J.-M. Fédéli, “Real-time cancellation of temperature induced resonance shifts in SOI wire waveguide ring resonator label-free biosensor arrays,” Opt. Express18(22), 22867–22879 (2010). [CrossRef] [PubMed]
- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
- D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express16(19), 15137–15148 (2008). [CrossRef] [PubMed]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- D.-X. Xu, M. Vachon, A. Densmore, R. Ma, S. Janz, A. Delâge, J. Lapointe, P. Cheben, J. H. Schmid, E. Post, S. Messaoudène, and J.-M. Fédéli, “Real-time cancellation of temperature induced resonance shifts in SOI wire waveguide ring resonator label-free biosensor arrays,” Opt. Express18(22), 22867–22879 (2010). [CrossRef] [PubMed]
- D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express16(19), 15137–15148 (2008). [CrossRef] [PubMed]
- D. R. Shankaran, K. V. Gobi, and N. Miura, “Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical, food and environmental interest,” Sens. Actuators B Chem.121(1), 158–177 (2007). [CrossRef]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- D.-X. Xu, M. Vachon, A. Densmore, R. Ma, S. Janz, A. Delâge, J. Lapointe, P. Cheben, J. H. Schmid, E. Post, S. Messaoudène, and J.-M. Fédéli, “Real-time cancellation of temperature induced resonance shifts in SOI wire waveguide ring resonator label-free biosensor arrays,” Opt. Express18(22), 22867–22879 (2010). [CrossRef] [PubMed]
- A. Delâge, D.-X. Xu, R. W. McKinnon, E. Post, P. Waldron, J. Lapointe, C. Storey, A. Densmore, S. Janz, B. Lamontagne, P. Cheben, and J. H. Schmid, “Wavelength-dependent model of a ring resonator sensor excited by a directional coupler,” J. Lightwave Technol.27(9), 1172–1180 (2009). [CrossRef]
- D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express16(19), 15137–15148 (2008). [CrossRef] [PubMed]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- D.-X. Xu, A. Delâge, J. H. Schmid, R. Ma, S. Wang, J. Lapointe, M. Vachon, P. Cheben, and S. Janz, “Selecting the polarization in silicon photonic wire components,” Proc. SPIE8266, 82660G, 82660G-9 (2012). [CrossRef]
- D.-X. Xu, M. Vachon, A. Densmore, R. Ma, S. Janz, A. Delâge, J. Lapointe, P. Cheben, J. H. Schmid, E. Post, S. Messaoudène, and J.-M. Fédéli, “Real-time cancellation of temperature induced resonance shifts in SOI wire waveguide ring resonator label-free biosensor arrays,” Opt. Express18(22), 22867–22879 (2010). [CrossRef] [PubMed]
- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
- A. Delâge, D.-X. Xu, R. W. McKinnon, E. Post, P. Waldron, J. Lapointe, C. Storey, A. Densmore, S. Janz, B. Lamontagne, P. Cheben, and J. H. Schmid, “Wavelength-dependent model of a ring resonator sensor excited by a directional coupler,” J. Lightwave Technol.27(9), 1172–1180 (2009). [CrossRef]
- D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express16(19), 15137–15148 (2008). [CrossRef] [PubMed]
- S. Selvaraja, W. Bogaerts, P. Dumon, D. Van Thourhout, and R. Baets, “Sub-nanometer linewidth uniformity in silicon nano-photonic waveguide devices using CMOS fabrication technology,” IEEE J. Sel. Top. Quantum Electron.16(1), 316–324 (2010). [CrossRef]
- D. R. Shankaran, K. V. Gobi, and N. Miura, “Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical, food and environmental interest,” Sens. Actuators B Chem.121(1), 158–177 (2007). [CrossRef]
- X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta620(1-2), 8–26 (2008). [CrossRef] [PubMed]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- M. Iqbal, M. A. Gleeson, B. Spaugh, F. Tybor, W. G. Gunn, M. Hochberg, T. Baehr-Jones, R. C. Bailey, and L. C. Gunn, “Label-free biosensor arrays based on silicon ring resonators and high-speed optical scanning instrumentation,” IEEE J. Sel. Top. Quantum Electron.16(3), 654–661 (2010). [CrossRef]
- X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta620(1-2), 8–26 (2008). [CrossRef] [PubMed]
- X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta620(1-2), 8–26 (2008). [CrossRef] [PubMed]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- M. Iqbal, M. A. Gleeson, B. Spaugh, F. Tybor, W. G. Gunn, M. Hochberg, T. Baehr-Jones, R. C. Bailey, and L. C. Gunn, “Label-free biosensor arrays based on silicon ring resonators and high-speed optical scanning instrumentation,” IEEE J. Sel. Top. Quantum Electron.16(3), 654–661 (2010). [CrossRef]
- D.-X. Xu, A. Delâge, J. H. Schmid, R. Ma, S. Wang, J. Lapointe, M. Vachon, P. Cheben, and S. Janz, “Selecting the polarization in silicon photonic wire components,” Proc. SPIE8266, 82660G, 82660G-9 (2012). [CrossRef]
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- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
- W. Bogaerts, P. De Heyn, T. Van Vaerenbergh, K. De Vos, S. Kumar Selvaraja, T. Claes, P. Dumon, P. Bienstman, D. Van Thourhout, and R. Baets, “Silicon microring resonators,” Laser Photonics Rev.6(1), 47–73 (2012). [CrossRef]
- S. Selvaraja, W. Bogaerts, P. Dumon, D. Van Thourhout, and R. Baets, “Sub-nanometer linewidth uniformity in silicon nano-photonic waveguide devices using CMOS fabrication technology,” IEEE J. Sel. Top. Quantum Electron.16(1), 316–324 (2010). [CrossRef]
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- A. Delâge, D.-X. Xu, R. W. McKinnon, E. Post, P. Waldron, J. Lapointe, C. Storey, A. Densmore, S. Janz, B. Lamontagne, P. Cheben, and J. H. Schmid, “Wavelength-dependent model of a ring resonator sensor excited by a directional coupler,” J. Lightwave Technol.27(9), 1172–1180 (2009). [CrossRef]
- D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express16(19), 15137–15148 (2008). [CrossRef] [PubMed]
- D.-X. Xu, A. Delâge, J. H. Schmid, R. Ma, S. Wang, J. Lapointe, M. Vachon, P. Cheben, and S. Janz, “Selecting the polarization in silicon photonic wire components,” Proc. SPIE8266, 82660G, 82660G-9 (2012). [CrossRef]
- X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta620(1-2), 8–26 (2008). [CrossRef] [PubMed]
- D.-X. Xu, A. Delâge, J. H. Schmid, R. Ma, S. Wang, J. Lapointe, M. Vachon, P. Cheben, and S. Janz, “Selecting the polarization in silicon photonic wire components,” Proc. SPIE8266, 82660G, 82660G-9 (2012). [CrossRef]
- D.-X. Xu, M. Vachon, A. Densmore, R. Ma, S. Janz, A. Delâge, J. Lapointe, P. Cheben, J. H. Schmid, E. Post, S. Messaoudène, and J.-M. Fédéli, “Real-time cancellation of temperature induced resonance shifts in SOI wire waveguide ring resonator label-free biosensor arrays,” Opt. Express18(22), 22867–22879 (2010). [CrossRef] [PubMed]
- A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, “Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection,” Opt. Lett.34(23), 3598–3600 (2009). [CrossRef] [PubMed]
- A. Delâge, D.-X. Xu, R. W. McKinnon, E. Post, P. Waldron, J. Lapointe, C. Storey, A. Densmore, S. Janz, B. Lamontagne, P. Cheben, and J. H. Schmid, “Wavelength-dependent model of a ring resonator sensor excited by a directional coupler,” J. Lightwave Technol.27(9), 1172–1180 (2009). [CrossRef]
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- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
- X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta620(1-2), 8–26 (2008). [CrossRef] [PubMed]
Anal. Chim. Acta
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IEEE J. Sel. Top. Quantum Electron.
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IEEE Photonics J.
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Proc. SPIE
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Other
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- D.-X. Xu, A. Delâge, J. H. Schmid, R. Ma, S. Wang, J. Lapointe, M. Vachon, P. Cheben, and S. Janz, “Selecting the polarization in silicon photonic wire components,” Proc. SPIE8266, 82660G, 82660G-9 (2012). [CrossRef]
- A. V. Krishnamoorthy, X. Zheng, G. Li, J. Yao, T. Pinguet, A. Mekis, H. Thacker, I. Shubin, Y. Luo, K. Raj, and J. E. Cunningham, “Exploiting CMOS manufacturing to reduce tuning requirements for resonant optical devices,” IEEE Photonics J.3(3), 567–579 (2011). [CrossRef]
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- M. Iqbal, M. A. Gleeson, B. Spaugh, F. Tybor, W. G. Gunn, M. Hochberg, T. Baehr-Jones, R. C. Bailey, and L. C. Gunn, “Label-free biosensor arrays based on silicon ring resonators and high-speed optical scanning instrumentation,” IEEE J. Sel. Top. Quantum Electron.16(3), 654–661 (2010). [CrossRef]
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- X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta620(1-2), 8–26 (2008). [CrossRef] [PubMed]
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- D. R. Shankaran, K. V. Gobi, and N. Miura, “Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical, food and environmental interest,” Sens. Actuators B Chem.121(1), 158–177 (2007). [CrossRef]
- W. Lukosz, “Priciples and sensitivities of integrated optical and surface plasmon sensors for direct affinity sensing and immunosensing,” Biosens. Bioelectron.6(3), 215–225 (1991). [CrossRef]
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