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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 28 — Dec. 31, 2012
  • pp: 29479–29487

Thermal stability of biodegradable plasmonic nanoclusters in photoacoustic imaging

Soon Joon Yoon, Avinash Murthy, Keith P. Johnston, Konstantin V. Sokolov, and Stanislav Y. Emelianov  »View Author Affiliations

Optics Express, Vol. 20, Issue 28, pp. 29479-29487 (2012)

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The photothermal stability of plasmonic nanoparticles is critically important to perform reliable photoacoustic imaging and photothermal therapy. Recently, biodegradable nanoclusters composed of sub-5 nm primary gold particles and a biodegradable polymer have been reported as clinically-translatable contrast agents for photoacoustic imaging. After cellular internalization, the nanoclusters degrade into 5 nm primary particles for efficient excretion from the body. In this paper, three different sizes of biodegradable nanoclusters were synthesized and the optical properties and photothermal stability of the nanoclusters were investigated and compared to that of gold nanorods. The results of our study indicate that 40 nm and 80 nm biodegradable nanoclusters demonstrate higher photothermal stability compared to gold nanorods. Furthermore, 40 nm nanoclusters produce higher photoacoustic signal than gold nanorods at a given concentration of gold. Therefore, the biodegradable plasmonic nanoclusters can be effectively used for photoacoustic imaging and photothermal therapy.

© 2012 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 25, 2012
Revised Manuscript: December 2, 2012
Manuscript Accepted: December 9, 2012
Published: December 19, 2012

Virtual Issues
Vol. 8, Iss. 1 Virtual Journal for Biomedical Optics

Soon Joon Yoon, Avinash Murthy, Keith P. Johnston, Konstantin V. Sokolov, and Stanislav Y. Emelianov, "Thermal stability of biodegradable plasmonic nanoclusters in photoacoustic imaging," Opt. Express 20, 29479-29487 (2012)

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  1. Y. Xia, P. Yang, Y. Sun, Y. Wu, B. Mayers, B. Gates, Y. Yin, F. Kim, and H. Yan, “One-dimensional nanostructures: synthesis, characterization, and applications,” Adv. Mater. (Deerfield Beach Fla.)15(5), 353–389 (2003). [CrossRef]
  2. R. Elghanian, J. J. Storhoff, R. C. Mucic, R. L. Letsinger, and C. A. Mirkin, “Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles,” Science277(5329), 1078–1081 (1997). [CrossRef] [PubMed]
  3. Y. C. Cao, R. C. Jin, and C. A. Mirkin, “Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection,” Science297(5586), 1536–1540 (2002). [CrossRef] [PubMed]
  4. L. R. Hirsch, R. J. Stafford, J. A. Bankson, S. R. Sershen, B. Rivera, R. E. Price, J. D. Hazle, N. J. Halas, and J. L. West, “Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance,” Proc. Natl. Acad. Sci. U.S.A.100(23), 13549–13554 (2003). [CrossRef] [PubMed]
  5. D. A. Giljohann and C. A. Mirkin, “Drivers of biodiagnostic development,” Nature462(7272), 461–464 (2009). [CrossRef] [PubMed]
  6. J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater.7(6), 442–453 (2008). [CrossRef] [PubMed]
  7. S. Rana, A. Bajaj, R. Mout, and V. M. Rotello, “Monolayer coated gold nanoparticles for delivery applications,” Adv. Drug Deliv. Rev.64(2), 200–216 (2012). [CrossRef] [PubMed]
  8. K. Sokolov, M. Follen, J. Aaron, I. Pavlova, A. Malpica, R. Lotan, and R. Richards-Kortum, “Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles,” Cancer Res.63(9), 1999–2004 (2003). [PubMed]
  9. S. Kumar, N. Harrison, R. Richards-Kortum, and K. Sokolov, “Plasmonic nanosensors for imaging intracellular biomarkers in live cells,” Nano Lett.7(5), 1338–1343 (2007). [CrossRef] [PubMed]
  10. J. Aaron, K. Travis, N. Harrison, and K. Sokolov, “Dynamic imaging of molecular assemblies in live cells based on nanoparticle plasmon resonance coupling,” Nano Lett.9(10), 3612–3618 (2009). [CrossRef] [PubMed]
  11. M. S. Yavuz, Y. Cheng, J. Chen, C. M. Cobley, Q. Zhang, M. Rycenga, J. Xie, C. Kim, K. H. Song, A. G. Schwartz, L. V. Wang, and Y. Xia, “Gold nanocages covered by smart polymers for controlled release with near-infrared light,” Nat. Mater.8(12), 935–939 (2009). [CrossRef] [PubMed]
  12. P. Alivisatos, “The use of nanocrystals in biological detection,” Nat. Biotechnol.22(1), 47–52 (2004). [CrossRef] [PubMed]
  13. X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, “Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy,” Nanomedicine (Lond)2(5), 681–693 (2007). [CrossRef] [PubMed]
  14. A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys.102(6), 064701 (2007). [CrossRef]
  15. Y.-S. Chen, W. Frey, S. Kim, K. Homan, P. Kruizinga, K. Sokolov, and S. Emelianov, “Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy,” Opt. Express18(9), 8867–8878 (2010). [CrossRef] [PubMed]
  16. K. Homan, S. Kim, Y.-S. Chen, B. Wang, S. Mallidi, and S. Emelianov, “Prospects of molecular photoacoustic imaging at 1064 nm wavelength,” Opt. Lett.35(15), 2663–2665 (2010). [CrossRef] [PubMed]
  17. K. H. Song, C. Kim, K. Maslov, and L. V. Wang, “Noninvasive in vivo spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes,” Eur. J. Radiol.70(2), 227–231 (2009). [CrossRef] [PubMed]
  18. S. Y. Emelianov, P. C. Li, and M. O’Donnell, “Photoacoustics for molecular imaging and therapy,” Phys. Today62(5), 34–39 (2009). [CrossRef] [PubMed]
  19. S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, “Molecular specific optoacoustic imaging with plasmonic nanoparticles,” Opt. Express15(11), 6583–6588 (2007). [CrossRef] [PubMed]
  20. B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009). [CrossRef] [PubMed]
  21. J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008). [CrossRef] [PubMed]
  22. Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan, and S. Emelianov, “Silica-coated gold nanorods as photoacoustic signal nanoamplifiers,” Nano Lett.11(2), 348–354 (2011). [CrossRef] [PubMed]
  23. N. Lewinski, V. Colvin, and R. Drezek, “Cytotoxicity of nanoparticles,” Small4(1), 26–49 (2008). [CrossRef] [PubMed]
  24. H. S. Choi, W. Liu, P. Misra, E. Tanaka, J. P. Zimmer, B. Itty Ipe, M. G. Bawendi, and J. V. Frangioni, “Renal clearance of quantum dots,” Nat. Biotechnol.25(10), 1165–1170 (2007). [CrossRef] [PubMed]
  25. P. K. Jain, K. S. Lee, I. H. El-Sayed, and M. A. El-Sayed, “Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine,” J. Phys. Chem. B110(14), 7238–7248 (2006). [CrossRef] [PubMed]
  26. J. M. Tam, J. O. Tam, A. Murthy, D. R. Ingram, L. L. Ma, K. Travis, K. P. Johnston, and K. V. Sokolov, “Controlled assembly of biodegradable plasmonic nanoclusters for near-infrared imaging and therapeutic applications,” ACS Nano4(4), 2178–2184 (2010). [CrossRef] [PubMed]
  27. S. J. Yoon, S. Mallidi, J. M. Tam, J. O. Tam, A. Murthy, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Utility of biodegradable plasmonic nanoclusters in photoacoustic imaging,” Opt. Lett.35(22), 3751–3753 (2010). [CrossRef] [PubMed]
  28. Y. T. Wang, S. Teitel, and C. Dellago, “Surface-driven bulk reorganization of gold nanorods,” Nano Lett.5(11), 2174–2178 (2005). [CrossRef] [PubMed]
  29. L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt.15(1), 016010 (2010). [CrossRef] [PubMed]
  30. J. M. Tam, A. K. Murthy, D. R. Ingram, R. Nguyen, K. V. Sokolov, and K. P. Johnston, “Kinetic assembly of near-IR-active gold nanoclusters using weakly adsorbing polymers to control the size,” Langmuir26(11), 8988–8999 (2010). [CrossRef] [PubMed]
  31. N. R. Jana, L. Gearheart, and C. J. Murphy, “Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template,” Adv. Mater. (Deerfield Beach Fla.)13(18), 1389–1393 (2001). [CrossRef]
  32. B. Nikoobakht and M. A. El-Sayed, “Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method,” Chem. Mater.15(10), 1957–1962 (2003). [CrossRef]
  33. American National Standard for the Safe Use of Lasers ANSI Z136.1–2000 (American National Standards Institute, Inc., New York, 2000).
  34. A. Sanchot, G. Baffou, R. Marty, A. Arbouet, R. Quidant, C. Girard, and E. Dujardin, “Plasmonic nanoparticle networks for light and heat concentration,” ACS Nano6(4), 3434–3440 (2012). [CrossRef] [PubMed]
  35. S. Y. Nam, L. M. Ricles, L. J. Suggs, and S. Y. Emelianov, “Nonlinear photoacoustic signal increase from endocytosis of gold nanoparticles,” Opt. Lett.37(22), 4708–4710 (2012). [PubMed]
  36. C. L. Bayer, S. Y. Nam, Y.-S. Chen, and S. Y. Emelianov, “Photoacoustic signal amplification through plasmonic nanoparticle aggregation,” J. Biomed. Opt. 18(1), in print (2013).
  37. W. Evans, R. Prasher, J. Fish, P. Meakin, P. Phelan, and P. Keblinski, “Effect of aggregation and interfacial thermal resistance on thermal conductivity of nanocomposites and colloidal nanofluids,” Int. J. Heat Mass Transfer51(5-6), 1431–1438 (2008). [CrossRef]
  38. Z. Ge, Y. Kang, T. A. Taton, P. V. Braun, and D. G. Cahill, “Thermal transport in au-core polymer-shell nanoparticles,” Nano Lett.5(3), 531–535 (2005). [CrossRef] [PubMed]
  39. Y.-S. Chen, W. Frey, S. Aglyamov, and S. Emelianov, “Environment-dependent generation of photoacoustic waves from plasmonic nanoparticles,” Small8(1), 47–52 (2012). [CrossRef] [PubMed]

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