OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 3 — Jan. 30, 2012
  • pp: 3082–3090

Enhancement of photoacoustic image quality by sound speed correction: ex vivo evaluation

Changhan Yoon, Jeeun Kang, Seunghee Han, Yangmo Yoo, Tai-Kyong Song, and Jin Ho Chang  »View Author Affiliations

Optics Express, Vol. 20, Issue 3, pp. 3082-3090 (2012)

View Full Text Article

Enhanced HTML    Acrobat PDF (1863 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Real-time photoacoustic (PA) imaging involves beamforming methods using an assumed fixed sound speed, typically 1540 m/s in soft tissue. This leads to degradation of PA image quality because the true sound speed changes as PA signal propagates through different types of soft tissues: the range from 1450 m/s to 1600 m/s. This paper proposes a new method for estimating an optimal sound speed to enhance the cross-sectional PA image quality. The optimal sound speed is determined when coherent factor with the sound speed is maximized. The proposed method was validated through simulation and ex vivo experiments with microcalcification-contained breast cancer specimen. The experimental results demonstrated that the best lateral resolution of PA images of microcalcifications can be achieved when the optimal sound speed is utilized.

© 2012 OSA

OCIS Codes
(110.7170) Imaging systems : Ultrasound
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 2, 2011
Revised Manuscript: January 17, 2012
Manuscript Accepted: January 18, 2012
Published: January 25, 2012

Virtual Issues
Vol. 7, Iss. 3 Virtual Journal for Biomedical Optics

Changhan Yoon, Jeeun Kang, Seunghee Han, Yangmo Yoo, Tai-Kyong Song, and Jin Ho Chang, "Enhancement of photoacoustic image quality by sound speed correction: ex vivo evaluation," Opt. Express 20, 3082-3090 (2012)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol.24(7), 848–851 (2006). [CrossRef] [PubMed]
  2. R. I. Siphanto, K. K. Thumma, R. G. M. Kolkman, T. G. van Leeuwen, F. F. M. de Mul, J. W. van Neck, L. N. A. van Adrichem, and W. Steenbergen, “Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis,” Opt. Express13(1), 89–95 (2005). [CrossRef] [PubMed]
  3. M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum.77(4), 0411011 (2006). [CrossRef]
  4. T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology256(1), 102–110 (2010). [CrossRef] [PubMed]
  5. X. Wang, J. B. Fowlkes, J. M. Cannata, C. Hu, and P. L. Carson, “Photoacoustic imaging with a commercial ultrasound system and a custom probe,” Ultrasound Med. Biol.37(3), 484–492 (2011). [CrossRef] [PubMed]
  6. T. Harrison and R. J. Zemp, “The applicability of ultrasound dynamic receive beamformers to photoacoustic imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control58(10), 2259–2263 (2011). [CrossRef] [PubMed]
  7. C.-K. Liao, M.-L. Li, and P.-C. Li, “Optoacoustic imaging with synthetic aperture focusing and coherence weighting,” Opt. Lett.29(21), 2506–2508 (2004). [CrossRef] [PubMed]
  8. S. Park, A. B. Karpiouk, S. R. Aglyamov, and S. Y. Emelianov, “Adaptive beamforming for photoacoustic imaging,” Opt. Lett.33(12), 1291–1293 (2008). [CrossRef] [PubMed]
  9. C. Yoon, Y. Lee, J. H. Chang, T.-K. Song, and Y. Yoo, “In vitro estimation of mean sound speed based on minimum average phase variance in medical ultrasound imaging,” Ultrasonics51(7), 795–802 (2011). [CrossRef] [PubMed]
  10. B. E. Treeby, T. K. Varslot, E. Z. Zhang, J. G. Laufer, and P. C. Beard, “Automatic sound speed selection in photoacoustic image reconstruction using an autofocus approach,” J. Biomed. Opt.16(9), 090501 (2011). [CrossRef] [PubMed]
  11. R. G. M. Kolkman, W. Steenbergen, and T. G. van Leeuwen, “Reflection mode photoacoustic measurement of speed of sound,” Opt. Express15(6), 3291–3300 (2007). [CrossRef] [PubMed]
  12. K. P. Köstli and P. C. Beard, “Two-dimensional photoacoustic imaging by use of Fourier-transform image reconstruction and a detector with an anisotropic response,” Appl. Opt.42(10), 1899–1908 (2003). [CrossRef] [PubMed]
  13. B. E. Treeby and B. T. Cox, “k-Wave: MATLAB toolbox for the simulation and reconstruction of photoacoustic wave fields,” J. Biomed. Opt.15(2), 021314 (2010). [CrossRef] [PubMed]
  14. J. Kang, E. K. Kim, J. Y. Kwak, Y. Yoo, T.-K. Song, and J. H. Chang, “Optimal laser wavelength for photoacoustic imaging of breast microcalcification,” Appl. Phys. Lett.99(15), 153702 (2011). [CrossRef]
  15. C. R. Hill, J. C. Bamber, and G. Haar, “Physical principles of medical ultrasonics (John Wiley and Sons, 2004), Chap. 5.
  16. S. W. Flax and M. O’Donnell, “Phase-aberration correction using signals from point reflector and diffuse scatterers: basic principles,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control35(6), 758–767 (1988). [CrossRef]
  17. C. I. Nilsen and S. Holm, “Wiener beamforming and the coherence factor in ultrasound imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control57(6), 1329–1346 (2010). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited