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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 4 — Feb. 13, 2012
  • pp: 4484–4493

All-fiber laser source for CARS microscopy based on fiber optical parametric frequency conversion

Martin Baumgartl, Mario Chemnitz, Cesar Jauregui, Tobias Meyer, Benjamin Dietzek, Jürgen Popp, Jens Limpert, and Andreas Tünnermann  »View Author Affiliations


Optics Express, Vol. 20, Issue 4, pp. 4484-4493 (2012)
http://dx.doi.org/10.1364/OE.20.004484


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Abstract

A novel approach for an all-fiber mono-laser source for CARS microscopy is presented. An Yb-fiber laser generates 100 ps pulses, which later undergo narrowband in-fiber frequency conversion based on degenerate four-wave-mixing. The frequency conversion is optimized to access frequency shifts between 900 and 3200cm−1, relevant for vibrational imaging. Inherently synchronized pump and Stokes pulses are available at one fiber end, readily overlapped in space and time. The source is applied to CARS spectroscopy and microscopy experiments in the CH-stretching region around 3000cm−1. Due to its simplicity and maintenance-free operation, the laser scheme holds great potential for bio-medical applications outside laser laboratories.

© 2012 OSA

OCIS Codes
(060.4370) Fiber optics and optical communications : Nonlinear optics, fibers
(140.7300) Lasers and laser optics : Visible lasers
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(190.4370) Nonlinear optics : Nonlinear optics, fibers
(190.4380) Nonlinear optics : Nonlinear optics, four-wave mixing
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Lasers and Laser Optics

History
Original Manuscript: December 7, 2011
Revised Manuscript: January 18, 2012
Manuscript Accepted: January 18, 2012
Published: February 8, 2012

Virtual Issues
Vol. 7, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Martin Baumgartl, Mario Chemnitz, Cesar Jauregui, Tobias Meyer, Benjamin Dietzek, Jürgen Popp, Jens Limpert, and Andreas Tünnermann, "All-fiber laser source for CARS microscopy based on fiber optical parametric frequency conversion," Opt. Express 20, 4484-4493 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-4-4484


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References

  1. C. L. Evans and X. S. Xie, “Coherent anti-stokes Raman scattering microscopy: chemical imaging for biology and medicine,” Annu Rev Anal Chem (Palo Alto Calif)1(1), 883–909 (2008). [CrossRef] [PubMed]
  2. A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering,” Phys. Rev. Lett.82(20), 4142–4145 (1999). [CrossRef]
  3. K. Kieu, B. G. Saar, G. R. Holtom, X. S. Xie, and F. W. Wise, “High-power picosecond fiber source for coherent Raman microscopy,” Opt. Lett.34(13), 2051–2053 (2009). [CrossRef] [PubMed]
  4. E. R. Andresen, C. K. Nielsen, J. Thøgersen, and S. R. Keiding, “Fiber laser-based light source for coherent anti-Stokes Raman scattering microspectroscopy,” Opt. Express15(8), 4848–4856 (2007). [CrossRef] [PubMed]
  5. A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, J. P. Pezacki, B. K. Thomas, L. Fu, L. Dong, M. E. Fermann, and A. Stolow, “All-fiber CARS microscopy of live cells,” Opt. Express17(23), 20700–20706 (2009). [CrossRef] [PubMed]
  6. M. Marangoni, A. Gambetta, C. Manzoni, V. Kumar, R. Ramponi, and G. Cerullo, “Fiber-format CARS spectroscopy by spectral compression of femtosecond pulses from a single laser oscillator,” Opt. Lett.34(21), 3262–3264 (2009). [CrossRef] [PubMed]
  7. K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
  8. R. Selm, M. Winterhalder, A. Zumbusch, G. Krauss, T. Hanke, A. Sell, and A. Leitenstorfer, “Ultrabroadband background-free coherent anti-Stokes Raman scattering microscopy based on a compact Er:fiber laser system,” Opt. Lett.35(19), 3282–3284 (2010). [CrossRef] [PubMed]
  9. M. Balu, G. Liu, Z. Chen, B. J. Tromberg, and E. O. Potma, “Fiber delivered probe for efficient CARS imaging of tissues,” Opt. Express18(3), 2380–2388 (2010). [CrossRef] [PubMed]
  10. B. Ortaς, M. Plötner, T. Schreiber, J. Limpert, and A. Tünnermann, “Experimental and numerical study of pulse dynamics in positive net-cavity dispersion modelocked Yb-doped fiber lasers,” Opt. Express15, 15595–15602 (2007).
  11. W. Wadsworth, N. Joly, J. Knight, T. Birks, F. Biancalana, and P. Russell, “Supercontinuum and four-wave mixing with Q-switched pulses in endlessly single-mode photonic crystal fibres,” Opt. Express12(2), 299–309 (2004). [CrossRef] [PubMed]
  12. D. Nodop, C. Jauregui, D. Schimpf, J. Limpert, and A. Tünnermann, “Efficient high-power generation of visible and mid-infrared light by degenerate four-wave-mixing in a large-mode-area photonic-crystal fiber,” Opt. Lett.34(22), 3499–3501 (2009). [CrossRef] [PubMed]
  13. L. Lavoute, J. C. Knight, P. Dupriez, and W. J. Wadsworth, “High power red and near-IR generation using four wave mixing in all integrated fibre laser systems,” Opt. Express18(15), 16193–16205 (2010). [CrossRef] [PubMed]
  14. G. P. Agrawal, Nonlinear Fiber Optics (Academic, 2001).
  15. P. J. Mosley, S. A. Bateman, L. Lavoute, and W. J. Wadsworth, “Low-noise, high-brightness, tunable source of picosecond pulsed light in the near-infrared and visible,” Opt. Express19(25), 25337–25345 (2011). [CrossRef]
  16. A. Steinmetz, D. Nodop, A. Martin, J. Limpert, and A. Tünnermann, “Reduction of timing jitter in passively Q-switched microchip lasers using self-injection seeding,” Opt. Lett.35(17), 2885–2887 (2010). [CrossRef] [PubMed]

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