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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 7 — Mar. 26, 2012
  • pp: 6932–6943

Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dual-optical imaging techniques

Seungduk Lee, Dalkwon Koh, Areum Jo, Hae Young Lim, Young-Jin Jung, Choong-Ki Kim, Youngwook Seo, Chang-Hwan Im, Beop-Min Kim, and Minah Suh  »View Author Affiliations


Optics Express, Vol. 20, Issue 7, pp. 6932-6943 (2012)
http://dx.doi.org/10.1364/OE.20.006932


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Abstract

We studied depth-dependent cerebral hemodynamic responses of rat brain following direct cortical electrical stimulation (DCES) in vivo with optical recording of intrinsic signal (ORIS) and near-infrared spectroscopy (NIRS). ORIS is used to visualize the immediate hemodynamic changes in cortical areas following the stimulation, whereas NIRS measures the hemodynamic changes originating from subcortical areas. We found strong hemodynamic changes in relation to DCES both in ORIS and NIRS data. In particular, the signals originating from cortical areas exhibited a tri-phasic response, whereas those originating from subcortical regions exhibited multi-phasic responses. In addition, NIRS signals from two different sets of source-detector separation were compared and analyzed to investigate the causality of perfusion, which demonstrated downstream propagation, indicating that the upper brain region reacted faster than the deep region.

© 2012 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 28, 2011
Revised Manuscript: February 26, 2012
Manuscript Accepted: March 5, 2012
Published: March 12, 2012

Virtual Issues
Vol. 7, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Seungduk Lee, Dalkwon Koh, Areum Jo, Hae Young Lim, Young-Jin Jung, Choong-Ki Kim, Youngwook Seo, Chang-Hwan Im, Beop-Min Kim, and Minah Suh, "Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dual-optical imaging techniques," Opt. Express 20, 6932-6943 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-7-6932


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