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Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor applicationJon Olav Grepstad, Peter Kaspar, Olav Solgaard, Ib-Rune Johansen, and Aasmund S. Sudbø »View Author Affiliations
Jon Olav Grepstad,1,2,3,*
Peter Kaspar,4
Olav Solgaard,5
Ib-Rune Johansen,2
and Aasmund S. Sudbø6,3
1Department of Electronics and Telecommunications, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway 2SINTEF ICT, Microsystems and Nanotechnology, NO-0373, Norway 3University Graduate Center, NO-2027 Kjeller, Norway 4Electronics Laboratory, ETH Zurich, CH-8092 Zrich, Switzerland 5E.L. Ginzton Laboratory, Stanford University, CA-94305, USA 6Department of Physics, University of Oslo, NO-0316, Norway *Corresponding author: jonolav.grepstad@sintef.no |
Optics Express, Vol. 20, Issue 7, pp. 7954-7965 (2012)
http://dx.doi.org/10.1364/OE.20.007954
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Abstract
A sensor designed to detect bio-molecules is presented. The sensor exploits a planar 2D photonic crystal (PC) membrane with sub-micron thickness and through holes, to induce high optical fields that allow detection of nano-particles smaller than the diffraction limit of an optical microscope. We report on our design and fabrication of a PC membrane with a nano-particle trapped inside. We have also designed and built an imaging system where an optical microscope and a CCD camera are used to take images of the PC membrane. Results show how the trapped nano-particle appears as a bright spot in the image. In a first experimental realization of the imaging system, single particles with a radius of 75 nm can be detected.
© 2012 OSA
OCIS Codes
(220.0220) Optical design and fabrication : Optical design and fabrication
(280.4788) Remote sensing and sensors : Optical sensing and sensors
ToC Category:
Sensors
History
Original Manuscript: January 19, 2012
Revised Manuscript: March 15, 2012
Manuscript Accepted: March 16, 2012
Published: March 21, 2012
Virtual Issues
Vol. 7, Iss. 5 Virtual Journal for Biomedical Optics
Citation
Jon Olav Grepstad, Peter Kaspar, Olav Solgaard, Ib-Rune Johansen, and Aasmund S. Sudbø, "Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application," Opt. Express 20, 7954-7965 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-7-7954
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References
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- Y. Cui, Q. Wei, H. Park, and C. M. Lieber, “Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species,” Science293, 1289–1292 (2001). [CrossRef] [PubMed]
- M. F. Pineda, L. L. Chan, T. Kuhlenschmidt, C. J. Choi, M. Kuhlenschmidt, and B. T. Cunningham, “Rapid specific and label-free detection of porcine rotavirus using photonic crystal biosensors,” IEEE Sens. J.9, 470–477 (2009). [CrossRef]
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- J. Lee, K. Icoz, A. Roberts, A. D. Ellington, and C. A. Savran, “Diffractometric detection of proteins using microbead-based rolling circle amplification,” Anal. Chem.82, 197–202 (2010). [CrossRef]
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Appl. Optics
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Langmuir
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N. Engl. J. Med.
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Nat. Mater.
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Science
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Sens. Actuator B
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- J. Lee, K. Icoz, A. Roberts, A. D. Ellington, and C. A. Savran, “Diffractometric detection of proteins using microbead-based rolling circle amplification,” Anal. Chem.82, 197–202 (2010). [CrossRef]
- F. Hsiao and C. Lee, “Computational study of photonic crystals nano-ring resonator for biochemical sensing,” IEEE Sens. J.10, 1185–1191 (2010). [CrossRef]
- S. Zlatanovic, L. W. Mirkarimi, M. M. Sigalas, M. A. Bynum, E. Chow, K. M. Robotti, G. W. Burr, S. Esener, and A. Grot, “Photonic crystal microcavity sensor for ultracompact monitoring of reaction kinetics and protein concentration,” Sens. Actuator B141, 13–19 (2009). [CrossRef]
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- T. Reichlin, W. Hochholzer, S. Bassetti, S. Steuer, C. Stelzig, S. Hartwiger, S. Biedert, N. Schaub, C. Buerge, M. Potocki, M. Noveanu, T. Breidthardt, R. Twerenbold, K. Winkler, R. Bingisser, and C. Mueller, “Early diagnosis of myocardial infarction with sensitive cardiac troponinassays,” N. Engl. J. Med.361, 858–867 (2009). [CrossRef] [PubMed]
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- J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater.7, 442–453 (2008). [CrossRef] [PubMed]
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- E. Stern, R. Wagner, F. J. Sigworth, R. Breaker, T. M. Fahmy, and M. A. Reed, “Importance of the debye screening length on nanowire field effect transistor sensors,” Nano Lett.7, 3405–3409 (2007). [CrossRef] [PubMed]
- S. Lal, S. Link, and N. J. Halas, “Nano-optics from sensing to waveguiding,” Nat. Photonics1, 641–648 (2007). [CrossRef]
- A. Lesuffleur, H. Im, N.-C. Lindquist, and S. H. Oh, “Periodic nanohole arrays with shape-enhanced plasmon resonance as real-time biosensors,” Appl. Phys. Lett.90, 243110 (2007). [CrossRef]
- M. E. Stewart, N. H. Mack, V. Malyarchuk, J. A. N. T. Soares, T. W. Lee, S. K. Gray, R. G. Nuzzo, and J. A. Rogers, “Quantitative multispectral biosensing and 1d imaging using quasi-3d plasmonic crystals,” Proc. Natl. Acad. Sci. U. S. A.103, 17143–17148 (2006). [CrossRef] [PubMed]
- S. W. Bishnoi, C. J. Rozell, C. S. Levin, M. K. Gheith, B. R. Johnson, D. H. Johnson, and N. J. Halas, “All-optical nanoscale ph meter,” Nano Lett.6, 1687–1692 (2006). [CrossRef] [PubMed]
- A. K. Gupta, P. R. Nair, D. Akin, M. R. Ladisch, S. Broyles, M. A. Alam, and R. Bashir, “Anomalous resonance in a nanomechanical biosensor,” Proc. Natl. Acad. Sci. U. S. A.103, 13362–13367 (2006). [CrossRef] [PubMed]
- Y. L. Bunimovich, Y. S. Shin, W. Yeo, M. Amori, G. Kwong, and J. R. Heath, “Quantitative real-time measurements of dna hybridization with alkylated nonoxidized silicon nanowires in electrolyte solution,” J. Am. Chem. Soc.128, 16323–16331 (2006). [CrossRef] [PubMed]
- C. A. Savran, S. M. Knudsen, A. D. Ellington, and S. R. Manalis, “Micromechanical detection of proteins using aptamer-based receptor molecules,” Anal. Chem.76, 3194–3198 (2004). [CrossRef] [PubMed]
- A. G. Brolo, R. Gordon, B. Leathem, and K. L. Kavanagh, “Surface plasmon sensor based on the enhanced light transmission through arrays of nanoholes in gold films,” Langmuir20, 4813–4815 (2004). [CrossRef]
- J. Vrs, “The density and refractive index of adsorbing protein layers,” Biophys. J.87, 553–561 (2004). [CrossRef]
- S. Fan and J. D. Joannopoulos, “Analysis of guided resonances in photonic crystal slabs,” Phys. Rev. B65, 235112 (2002). [CrossRef]
- Y. Cui, Q. Wei, H. Park, and C. M. Lieber, “Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species,” Science293, 1289–1292 (2001). [CrossRef] [PubMed]
- J. Fritz, M. K. Baller, H. P. Lang, H. Rothuizen, P. Vettiger, E. Meyer, H. J. Gntherodt, C. Gerber, and J. K. Gimzewski, “Translating biomolecular recognition into nanomechanics,” Science288, 316–318 (2000). [CrossRef] [PubMed]
- M. Kanskar, P. Paddon, V. Pacradouni, R. Morin, A. Busch, J. F. Young, S. R. Johnson, J. MacKenzie, and T. Tiedje, “Observation of leaky slab modes in an air-bridged semiconductor waveguide with a two-dimensional photonic lattice,” Appl. Phys. Lett.70, 1438–1440 (1997). [CrossRef]
- M. G. Hale and M. R. Querry, “Optical constants of water in the 200-nm to 200-μm wavelength region,” Appl. Optics12, 555–563 (1973). [CrossRef]
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