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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 9 — Apr. 23, 2012
  • pp: 9476–9484

Terahertz dynamic imaging of skin drug absorption

Kyung Won Kim, Kwang-Sung Kim, Hyeongmun Kim, Sang Hun Lee, Jae-Hak Park, Ju-Hee Han, Seung-Hyeok Seok, Jisuk Park, YoonSeok Choi, Young Il Kim, Joon Koo Han, and Joo-Hiuk Son  »View Author Affiliations


Optics Express, Vol. 20, Issue 9, pp. 9476-9484 (2012)
http://dx.doi.org/10.1364/OE.20.009476


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Abstract

Terahertz (THz) imaging is a nondestructive, label-free, rapid imaging technique which gives the possibility of a real-time tracing of drugs within the skin. We evaluated the feasibility of THz dynamic imaging for visualizing serial changes in the distribution and penetration of a topical agent, dimethyl sulfoxide (DMSO) containing ketoprofen, using excised mouse skins. THz imaging was performed for 6 h after drug application to the skin and was compared with the results obtained using the Franz cell diffusion test, a standard in vitro skin absorption test. THz dynamic reflection imaging showed that the reflection signals decreased rapidly during the early time period, and remained constant through the late time period. The area of drug permeation within the skin layer on THz imaging increased with time. The dynamic pattern of THz reflection signal decrease was similar to that of DMSO absorption analyzed by the Franz cell diffusion test, which indicates that THz imaging mainly reflects the DMSO component. This study demonstrates that THz imaging technique can be used for imaging the spatial distribution and penetration of drug-applied sites.

© 2012 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.6795) Imaging systems : Terahertz imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 21, 2012
Revised Manuscript: March 22, 2012
Manuscript Accepted: March 23, 2012
Published: April 10, 2012

Virtual Issues
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Kyung Won Kim, Kwang-Sung Kim, Hyeongmun Kim, Sang Hun Lee, Jae-Hak Park, Ju-Hee Han, Seung-Hyeok Seok, Jisuk Park, YoonSeok Choi, Young Il Kim, Joon Koo Han, and Joo-Hiuk Son, "Terahertz dynamic imaging of skin drug absorption," Opt. Express 20, 9476-9484 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-9-9476


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