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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 10 — May. 20, 2013
  • pp: 12340–12350

Hollow core photonic crystal fiber as a reusable Raman biosensor

Altaf Khetani, Jason Riordon, Vidhu Tiwari, Ali Momenpour, Michel Godin, and Hanan Anis  »View Author Affiliations


Optics Express, Vol. 21, Issue 10, pp. 12340-12350 (2013)
http://dx.doi.org/10.1364/OE.21.012340


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Abstract

We report that a single hollow core photonic crystal fiber (HC-PCF) can be used for repetitive characterization of multiple samples by Raman spectroscopy. This was achieved by integrating the HC-PCF to a differential pressure system that allowed effective filling, draining and re-filling of samples into a HC-PCF under identical optical conditions. Consequently, high-quality and reliable spectral data could be obtained which were suitable for multivariate analysis (partial least squares). With the present scheme, we were able to accurately predict different concentrations of heparin and adenosine in serum. Thus the detection scheme as presented here paves a path for the inclusion of HC-PCFs in point-of-care technologies and environmental monitoring where rapid sample characterization is of utmost importance.

© 2013 OSA

OCIS Codes
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(280.4788) Remote sensing and sensors : Optical sensing and sensors
(060.5295) Fiber optics and optical communications : Photonic crystal fibers

ToC Category:
Sensors

History
Original Manuscript: February 25, 2013
Revised Manuscript: April 18, 2013
Manuscript Accepted: May 3, 2013
Published: May 13, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Altaf Khetani, Jason Riordon, Vidhu Tiwari, Ali Momenpour, Michel Godin, and Hanan Anis, "Hollow core photonic crystal fiber as a reusable Raman biosensor," Opt. Express 21, 12340-12350 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-10-12340


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