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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 10 — May. 20, 2013
  • pp: 12604–12610

Near-infrared femtosecond laser-triggered nanoperforation of hollow microcapsules

Mitsuhiro Terakawa, Tatsuki Mitsuhashi, Takuya Shinohara, and Hisashi Shimizu  »View Author Affiliations

Optics Express, Vol. 21, Issue 10, pp. 12604-12610 (2013)

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Fabrication of a nanopore in a hollow microcapsule was demonstrated using near-infrared femtosecond laser irradiation. The shape of the irradiated microcapsules was kept spherical except for a pore in the shell owing to the nonthermal processing by a femtosecond laser. The simulation results for the near-field and far-field scattering around a microcapsule revealed that highly-enhanced optical intensity can be generated at a spot on the shell of a microcapsule, which would in turn contribute to localized ablation. To the best of our knowledge, this is the first demonstration of the nanoperforation of transparent hollow microcapsules by a near-infrared laser without any doping with absorbing metals or dyes that may cause cell toxicity. The presented method is a promising approach for safer drug delivery and the controlled release of therapeutic drugs.

© 2013 OSA

OCIS Codes
(140.3390) Lasers and laser optics : Laser materials processing
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

ToC Category:
Laser Microfabrication

Original Manuscript: March 19, 2013
Revised Manuscript: May 9, 2013
Manuscript Accepted: May 11, 2013
Published: May 15, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Mitsuhiro Terakawa, Tatsuki Mitsuhashi, Takuya Shinohara, and Hisashi Shimizu, "Near-infrared femtosecond laser-triggered nanoperforation of hollow microcapsules," Opt. Express 21, 12604-12610 (2013)

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