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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 10 — May. 20, 2013
  • pp: 12815–12821

Selective detection of sub-atto-molar Streptavidin in 1013-fold impure sample using photonic crystal nanolaser sensors

Shoji Hachuda, Shota Otsuka, Shota Kita, Toshinari Isono, Michimasa Narimatsu, Keisuke Watanabe, Yoshio Goshima, and Toshihiko Baba  »View Author Affiliations

Optics Express, Vol. 21, Issue 10, pp. 12815-12821 (2013)

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Biosensors selectively detecting a very small amount of biomarker protein in human blood are desired for early and reliable diagnoses of severe diseases. This paper reports the detection of protein (streptavidin: SA) in ultra-low concentration, with an ultra-high selectivity against contaminants, using photonic crystal nanolasers. For biotin-modified nanolasers in pure water with SA, an extremely-low detection limit of 16 zM is evaluated. Even in a mixture with 1 μM bovine serum albumin as the contaminant, 100 zM SA is detected, meaning a selectivity of 1013. These are remarkable capabilities that are promising for practical biosensing in the medical applications mentioned above.

© 2013 OSA

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(140.3945) Lasers and laser optics : Microcavities
(230.5298) Optical devices : Photonic crystals

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 1, 2013
Revised Manuscript: May 13, 2013
Manuscript Accepted: May 14, 2013
Published: May 17, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Shoji Hachuda, Shota Otsuka, Shota Kita, Toshinari Isono, Michimasa Narimatsu, Keisuke Watanabe, Yoshio Goshima, and Toshihiko Baba, "Selective detection of sub-atto-molar Streptavidin in 1013-fold impure sample using photonic crystal nanolaser sensors," Opt. Express 21, 12815-12821 (2013)

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