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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 12 — Jun. 17, 2013
  • pp: 14120–14130

Polarimetric imaging of uterine cervix: a case study

Angelo Pierangelo, André Nazac, Abdelali Benali, Pierre Validire, Henri Cohen, Tatiana Novikova, Bicher Haj Ibrahim, Sandeep Manhas, Clément Fallet, Maria-Rosaria Antonelli, and Antonello-De Martino  »View Author Affiliations

Optics Express, Vol. 21, Issue 12, pp. 14120-14130 (2013)

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We present a preliminary investigation of macroscopic polarimetric imaging of uterine cervix. Orthogonal state contrast (OSC) images of healthy and anomalous cervices have been taken in vivo at 550 nm. Four ex vivo cervix samples have been studied in full Muller polarimetry, at 550 nm and 700 nm, and characterized in detail by standard pathology. One sample was totally healthy, another one carried CIN lesions at very early stage (CIN1) in its visible exocervical region, while for the other two samples more advanced (CIN3) lesions were present, together with visible glandular epithelium (ectropion). Significant birefringence has been observed in the healthy regions of all six samples, both in vivo and ex vivo. Standard treatments of the Mueller images of the ex vivo samples allowed to quantify both retardation and depolarization. Retardation reached 60° in healthy regions, and disappeared in the anomalous regions of the other three ex vivo samples. The depolarization power was largest in healthy regions, and lower in CINs and ectropion. Possible origins of the observed effects are briefly discussed.

© 2013 OSA

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(260.5430) Physical optics : Polarization
(110.5405) Imaging systems : Polarimetric imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 4, 2013
Revised Manuscript: April 5, 2013
Manuscript Accepted: April 25, 2013
Published: June 5, 2013

Virtual Issues
Vol. 8, Iss. 7 Virtual Journal for Biomedical Optics

Angelo Pierangelo, André Nazac, Abdelali Benali, Pierre Validire, Henri Cohen, Tatiana Novikova, Bicher Haj Ibrahim, Sandeep Manhas, Clément Fallet, Maria-Rosaria Antonelli, and Antonello-De Martino, "Polarimetric imaging of uterine cervix: a case study," Opt. Express 21, 14120-14130 (2013)

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