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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 13 — Jul. 1, 2013
  • pp: 15298–15307

Spatial-spectral coupling in coherent anti-Stokes Raman scattering microscopy

Aaron M. Barlow, Konstantin Popov, Marco Andreana, Douglas J. Moffatt, Andrew Ridsdale, Aaron D. Slepkov, James L. Harden, Lora Ramunno, and Albert Stolow  »View Author Affiliations


Optics Express, Vol. 21, Issue 13, pp. 15298-15307 (2013)
http://dx.doi.org/10.1364/OE.21.015298


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Abstract

Coherent anti-Stokes Raman scattering (CARS) microscopy is a third-order nonlinear optical technique which permits label-free, molecule-specific hyperspectral imaging. The interference between coherent resonant and non-resonant terms leads to well known distortions in the vibrational spectrum, requiring the use of retrieval algorithms. It also leads to spatial imaging distortions, largely due to the Gouy phase, when objects are smaller than the Rayleigh range. Here we consider that the focal position and spectral contributions to the nonlinear image formation are intrinsically coupled and cannot be corrected by conventional retrieval methods.

© 2013 OSA

OCIS Codes
(020.3690) Atomic and molecular physics : Line shapes and shifts
(030.1670) Coherence and statistical optics : Coherent optical effects
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Microscopy

History
Original Manuscript: April 30, 2013
Manuscript Accepted: June 9, 2013
Published: June 19, 2013

Virtual Issues
Vol. 8, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Aaron M. Barlow, Konstantin Popov, Marco Andreana, Douglas J. Moffatt, Andrew Ridsdale, Aaron D. Slepkov, James L. Harden, Lora Ramunno, and Albert Stolow, "Spatial-spectral coupling in coherent anti-Stokes Raman scattering microscopy," Opt. Express 21, 15298-15307 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-13-15298


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References

  1. A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-dimensional vibrational imaging by coherent anti-Stokes Raman scattering,” Phys. Rev. Lett.824142–4145 (1999). [CrossRef]
  2. E. O. Potma and X. S. Xie, “CARS microscopy for biology and medicine,” Opt. Photon. News15, 40–45 (2004). [CrossRef]
  3. C. L. Evans and X. S. Xie, “Coherent anti-Stokes Raman scattering microscopy: chemical imaging for biology and medicine,” Annu. Rev. Anal. Chem.1, 883–909 (2008). [CrossRef]
  4. J. Cheng, A. Volkmer, L. D. Book, and X. S. Xie, “An epi-detected coherent anti-Stokes Raman scattering (E-CARS) microscope with high spectral resolution and high sensitivity,” J. Phys. Chem. B105, 1277–1280 (2001). [CrossRef]
  5. L. Li, H. Wang, and J. Cheng, “Quantitative coherent anti-Stokes Raman scattering imaging of lipid distribution in coexisting domains”, Biophys. J.89, 3480–3490 (2005). [CrossRef] [PubMed]
  6. M. Müller and J. M. Schins, “Imaging the thermodynamic state of lipid membranes with multiplex CARS microscopy,” J. Phys. Chem.106, 3715–3723 (2002).
  7. S. H. Parekh, Y. J. Lee, K. A. Aamer, and M. T. Cicerone, “Label-free cellular imaging by broadband coherent anti-Stokes Raman scattering microscopy,” Biophys. J.99, 2695–2704 (2010). [CrossRef] [PubMed]
  8. A. F. Pegoraro, A. D. Slepkov, A. Ridsdale, D. J. Moffatt, and A. Stolow, “Hyperspectral multimodal CARS microscopy in the fingerprint region,” J. Biophotonics (2012) [CrossRef] [PubMed]
  9. C. Chung, J. Hsu, S. Mukamel, and E. O. Potma, “Controlling stimulated coherent spectroscopy and microscopy by a position-dependent phase,” Phys. Rev. A87, 033833 (2013). [CrossRef]
  10. S. Maeda, T. Kamisuki, and Y. Adachi, Advances in Non-linear Spectroscopy, R. J. H. Clark and R. E. Hester, eds. (John Wiley and Sons Ltd., 1988) p. 253.
  11. E. O. Potma, C. L. Evans, and X. S. Xie, “Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging,” Opt. Lett.31, 241–243 (2006). [CrossRef] [PubMed]
  12. W. M. Tolles, J. W. Nibler, J. R. McDonald, and A. B. Harvey, “A Review of the Theory and Applications of Coherent Anti-Stokes Raman Spectroscopy (CARS),” Appl. Spectrosc.31253–271 (1971). [CrossRef]
  13. Y. Liu, Y. J. Lee, and M. T. Cicerone, “Broadband CARS spectral phase retrieval using a time-domain Kramers-Kronig transform,” Opt. Lett.34, 1363–1365 (2009). [CrossRef] [PubMed]
  14. E. M. Vartiainen, H. A. Rinia, M. Müller, and M. Bonn, “Direct extraction of Raman line-shapes from congested CARS spectra,” Opt. Express14, 3622–3630 (2006). [CrossRef] [PubMed]
  15. G. L. Eesley, Coherent Raman Spectroscopy(Pergamon Press, 1981).
  16. E. O. Potma, W. P. de Boeij, and D. A. Wiersma, “Nonlinear coherent four-wave mixing in optical microscopy,” J. Opt. Soc. Am. B17, 1678–1684, (2000). [CrossRef]
  17. J. Cheng, A. Volkmer, and X. S. Xie, “Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy,” J. Opt. Soc. Am. B19, 1363–1375 (2002). [CrossRef]
  18. N. Djaker, D. Gachet, N. Sandeau, PF. Lenne, and H. Rigneault, “Refractive effects in coherent anti-Stokes Raman scattering microscopy,” Appl. Opt.45, 7005–7011 (2006). [CrossRef] [PubMed]
  19. K. I. Popov, A. F. Pegoraro, A. Stolow, and L. Ramunno, “Image formation in CARS microscopy: effect of the Gouy phase shift,” Opt. Express19, 5902–5911 (2011). [CrossRef] [PubMed]
  20. D. Gachet, F. Billard, N. Sandeau, and H. Rigneault, “Coherent anti-Stokes Raman scattering (CARS) microscopy imaging at interfaces: evidence of interference effects,” Opt. Express1510408–10420 (2007). [CrossRef] [PubMed]
  21. D. Gachet, F. Billard, and H. Rigneault, “Focused field symmetries for background-free coherent anti-Stokes Raman spectroscopy,” Phys. Rev. A77061802(R) 1–4 (2008). [CrossRef]
  22. D. Gachet, S. Brustlein, and H. Rigneault, “Revisiting the Youngs double slit experiment for background-free nonlinear Raman spectroscopy and microscopy,” Phys. Rev. Lett.104213905 1–4 (2010).
  23. C. V. Stephenson, W. C. Coburn, and W. S. Wilcox, “The vibrational spectra and assignments of nitrobenzene, phenyl isocyanate, phenyl isothiocyanate, thionylaniline and anisole”, Spectrochim. Acta17, 933–946 (1961). [CrossRef]
  24. A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” œ172984–2996 (2009).
  25. K. S. Yee, “Numerical solution of initial boundary value problems involving maxwell’s equations in isotropic media,” IEEE Trans. Ant. Prop.14, 302–307 (1966). [CrossRef]
  26. M. Fujii, M. Tahara, I. Sakagami, W. Freude, and P. Russer, “High-order FDTD and auxiliary differential equation formulation of optical pulse propagation in 2-D Kerr and Raman nonlinear dispersive media,” IEEE J. Quant. Electron.40, 175–182 (2004). [CrossRef]
  27. D. Vanderbilt and S. G. Louie, “A Monte Carlo simulated annealing approach to optimization over continuous variables,” J. Comput. Phys.56, 259–271 (1984). [CrossRef]

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