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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 18 — Sep. 9, 2013
  • pp: 21472–21484

Lipid detection in atherosclerotic human coronaries by spectroscopic intravascular photoacoustic imaging

Krista Jansen, Min Wu, Antonius F. W. van der Steen, and Gijs van Soest  »View Author Affiliations

Optics Express, Vol. 21, Issue 18, pp. 21472-21484 (2013)

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The presence of lipids in atherosclerotic coronary lesions is an important determinant of their potential to trigger acute coronary events. Spectroscopic intravascular photoacoustic imaging (sIVPA) has the potential to automatically detect lipids in atherosclerotic lesions. For real-time in vivo imaging, limiting the number of excitation wavelengths is crucial. We explored methods for plaque lipid detection using sIVPA, with the aim to minimize the number of laser pulses per image line. A combined intravascular ultrasound (IVUS) and photoacoustic imaging system was used to image a vessel phantom and human coronary arteries ex vivo. We acquired co-registered cross-sectional images at several wavelengths near 1200 nm, a lipid-specific absorption band. Correlating the photoacoustic spectra at 6 or 3 wavelengths from 1185 to 1235 nm with the absorption spectrum of cholesterol and peri-adventitial tissue, we could detect and differentiate the lipids in the atherosclerotic plaque and peri-adventitial lipids, respectively. With two wavelengths, both plaque and peri-adventitial lipids were detected but could not be distinguished.

© 2013 OSA

OCIS Codes
(110.7170) Imaging systems : Ultrasound
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.7170) Medical optics and biotechnology : Ultrasound
(110.4234) Imaging systems : Multispectral and hyperspectral imaging
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 21, 2013
Revised Manuscript: July 29, 2013
Manuscript Accepted: August 25, 2013
Published: September 5, 2013

Virtual Issues
Vol. 8, Iss. 10 Virtual Journal for Biomedical Optics

Krista Jansen, Min Wu, Antonius F. W. van der Steen, and Gijs van Soest, "Lipid detection in atherosclerotic human coronaries by spectroscopic intravascular photoacoustic imaging," Opt. Express 21, 21472-21484 (2013)

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