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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 22 — Nov. 4, 2013
  • pp: 27185–27196

Information-based analysis of X-ray in-line phase tomography with application to the detection of iron oxide nanoparticles in the brain

Hugo Rositi, Carole Frindel, Max Langer, Marlène Wiart, Cécile Olivier, Françoise Peyrin, and David Rousseau  »View Author Affiliations


Optics Express, Vol. 21, Issue 22, pp. 27185-27196 (2013)
http://dx.doi.org/10.1364/OE.21.027185


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Abstract

The study analyzes noise in X-ray in-line phase tomography in a biomedical context. The impact of noise on detection of iron oxide nanoparticles in mouse brain is assessed. The part of the noise due to the imaging system and the part due to biology are quantitatively expressed in a Neyman Pearson detection strategy with two models of noise. This represents a practical extension of previous work on noise in phase-contrast X-ray imaging which focused on the theoretical expression of the signal-to-noise ratio in mono-dimensional phantoms, taking account of the statistical noise of the imaging system only. We also report the impact of the phase retrieval step on detection performance. Taken together, this constitutes a general methodology of practical interest for quantitative extraction of information from X-ray in-line phase tomography, and is also relevant to assessment of contrast agents with a blob-like signature in high resolution imaging.

© 2013 OSA

OCIS Codes
(100.0100) Image processing : Image processing
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(340.6720) X-ray optics : Synchrotron radiation
(340.7440) X-ray optics : X-ray imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 12, 2013
Revised Manuscript: October 18, 2013
Manuscript Accepted: October 18, 2013
Published: November 1, 2013

Virtual Issues
Vol. 9, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Hugo Rositi, Carole Frindel, Max Langer, Marlène Wiart, Cécile Olivier, Françoise Peyrin, and David Rousseau, "Information-based analysis of X-ray in-line phase tomography with application to the detection of iron oxide nanoparticles in the brain," Opt. Express 21, 27185-27196 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-22-27185


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