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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 23 — Nov. 18, 2013
  • pp: 27905–27923

Measurement of absolute regional lung air volumes from near-field x-ray speckles

Andrew F. T. Leong, David M. Paganin, Stuart B. Hooper, Melissa L. Siew, and Marcus J. Kitchen  »View Author Affiliations


Optics Express, Vol. 21, Issue 23, pp. 27905-27923 (2013)
http://dx.doi.org/10.1364/OE.21.027905


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Abstract

Propagation-based phase contrast x-ray (PBX) imaging yields high contrast images of the lung where airways that overlap in projection coherently scatter the x-rays, giving rise to a speckled intensity due to interference effects. Our previous works have shown that total and regional changes in lung air volumes can be accurately measured from two-dimensional (2D) absorption or phase contrast images when the subject is immersed in a water-filled container. In this paper we demonstrate how the phase contrast speckle patterns can be used to directly measure absolute regional lung air volumes from 2D PBX images without the need for a water-filled container. We justify this technique analytically and via simulation using the transport-of-intensity equation and calibrate the technique using our existing methods for measuring lung air volume. Finally, we show the full capabilities of this technique for measuring regional differences in lung aeration.

© 2013 OSA

OCIS Codes
(100.5070) Image processing : Phase retrieval
(110.6150) Imaging systems : Speckle imaging
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(290.5850) Scattering : Scattering, particles
(340.7440) X-ray optics : X-ray imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 28, 2013
Revised Manuscript: October 21, 2013
Manuscript Accepted: October 21, 2013
Published: November 6, 2013

Virtual Issues
Vol. 9, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Andrew F. T. Leong, David M. Paganin, Stuart B. Hooper, Melissa L. Siew, and Marcus J. Kitchen, "Measurement of absolute regional lung air volumes from near-field x-ray speckles," Opt. Express 21, 27905-27923 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-23-27905


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