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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 25 — Dec. 16, 2013
  • pp: 30282–30294

Holographic optical tweezers combined with back-focal-plane displacement detection

Ferran Marsà, Arnau Farré, Estela Martín-Badosa, and Mario Montes-Usategui  »View Author Affiliations


Optics Express, Vol. 21, Issue 25, pp. 30282-30294 (2013)
http://dx.doi.org/10.1364/OE.21.030282


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Abstract

A major problem with holographic optical tweezers (HOTs) is their incompatibility with laser-based position detection methods, such as back-focal-plane interferometry (BFPI). The alternatives generally used with HOTs, like high-speed video tracking, do not offer the same spatial and temporal bandwidths. This has limited the use of this technique in precise quantitative experiments. In this paper, we present an optical trap design that combines digital holography and back-focal-plane displacement detection. We show that, with a particularly simple setup, it is possible to generate a set of multiple holographic traps and an additional static non-holographic trap with orthogonal polarizations and that they can be, therefore, easily separated for measuring positions and forces with the high positional and temporal resolutions of laser-based detection. We prove that measurements from both polarizations contain less than 1% crosstalk and that traps in our setup are harmonic within the typical range. We further tested the instrument in a DNA stretching experiment and we discuss an interesting property of this configuration: the small drift of the differential signal between traps.

© 2013 Optical Society of America

OCIS Codes
(140.7010) Lasers and laser optics : Laser trapping
(170.4520) Medical optics and biotechnology : Optical confinement and manipulation
(230.6120) Optical devices : Spatial light modulators
(350.4855) Other areas of optics : Optical tweezers or optical manipulation

ToC Category:
Optical Trapping and Manipulation

History
Original Manuscript: October 4, 2013
Revised Manuscript: November 19, 2013
Manuscript Accepted: November 19, 2013
Published: December 3, 2013

Virtual Issues
Vol. 9, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Ferran Marsà, Arnau Farré, Estela Martín-Badosa, and Mario Montes-Usategui, "Holographic optical tweezers combined with back-focal-plane displacement detection," Opt. Express 21, 30282-30294 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-25-30282


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