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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 26 — Dec. 30, 2013
  • pp: 32151–32159

Phase-diverse Fresnel coherent diffractive imaging of malaria parasite-infected red blood cells in the water window

M. W.M. Jones, B. Abbey, A. Gianoncelli, E. Balaur, C. Millet, M. B Luu, H. D. Coughlan, A. J. Carroll, A. G. Peele, L. Tilley, and G. A. van Riessen  »View Author Affiliations


Optics Express, Vol. 21, Issue 26, pp. 32151-32159 (2013)
http://dx.doi.org/10.1364/OE.21.032151


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Abstract

Phase-diverse Fresnel coherent diffractive imaging has been shown to reveal the structure and composition of biological specimens with high sensitivity at nanoscale resolution. However, the method has yet to be applied using X-ray illumination with energy in the so-called ‘water-window’ that lies between the carbon and oxygen K edges. In this range, differences in the strength of the X-ray interaction for protein based biological materials and water is increased. Here we demonstrate a proof-of-principle application of FCDI at an X-ray energy within the water-window to a dehydrated cellular sample composed of red blood cells infected with the trophozoite stage of the malaria parasite, Plasmodium falciparum. Comparison of the results to both optical and electron microscopy shows that the correlative imaging methods that include water-window FCDI will find utility in studying cellular architecture.

© 2013 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(340.7440) X-ray optics : X-ray imaging
(340.7460) X-ray optics : X-ray microscopy
(260.6048) Physical optics : Soft x-rays

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 14, 2013
Revised Manuscript: November 19, 2013
Manuscript Accepted: November 20, 2013
Published: December 18, 2013

Virtual Issues
Vol. 9, Iss. 2 Virtual Journal for Biomedical Optics

Citation
M. W.M. Jones, B. Abbey, A. Gianoncelli, E. Balaur, C. Millet, M. B Luu, H. D. Coughlan, A. J. Carroll, A. G. Peele, L. Tilley, and G. A. van Riessen, "Phase-diverse Fresnel coherent diffractive imaging of malaria parasite-infected red blood cells in the water window," Opt. Express 21, 32151-32159 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-26-32151


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