OSA's Digital Library

Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 4 — Feb. 25, 2013
  • pp: 5025–5034

Using high frequency Raman spectra for colonic neoplasia detection

Michael A. Short, Isabella T. Tai, David Owen, and Haishan Zeng  »View Author Affiliations


Optics Express, Vol. 21, Issue 4, pp. 5025-5034 (2013)
http://dx.doi.org/10.1364/OE.21.005025


View Full Text Article

Enhanced HTML    Acrobat PDF (1368 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Raman systems have tremendous potential as adjunct devices for endoscopes to improve the identification of early colon cancers. However, the traditional low frequency (LF) measurement range has several obstacles that make it challenging to develop a routine clinical tool. An alternative is to use high frequency (HF) range. To test this idea Raman spectra were obtained in both the LF and HF ranges from the same colon lesions. Multivariate analyses predicted the pathology with high sensitivity and specificity for both the LF and HF data sets. This suggests that Raman systems that measure HF spectra, and are simpler to adopt into the clinic, could be used in vivo to improve the identification of neoplastic lesions.

© 2013 OSA

OCIS Codes
(000.1430) General : Biology and medicine
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 3, 2012
Revised Manuscript: February 14, 2013
Manuscript Accepted: February 15, 2013
Published: February 21, 2013

Virtual Issues
Vol. 8, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Michael A. Short, Isabella T. Tai, David Owen, and Haishan Zeng, "Using high frequency Raman spectra for colonic neoplasia detection," Opt. Express 21, 5025-5034 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-4-5025


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. E. P. Whitlock, J. S. Lin, E. Liles, T. L. Beil, and R. Fu, “Screening for colorectal cancer: a targeted, updated systematic review for the U.S. Preventive Services Task Force,” Ann. Intern. Med.149(9), 638–658 (2008). [PubMed]
  2. A. Adler, J. Aschenbeck, T. Yenerim, M. Mayr, A. Aminalai, R. Drossel, A. Schröder, M. Scheel, B. Wiedenmann, and T. Rösch, “Narrow-band versus white-light high definition television endoscopic imaging for screening colonoscopy: a prospective randomized trial,” Gastroenterology136(2), 410–416 quiz 715 (2009). [CrossRef] [PubMed]
  3. A. Stallmach, C. Schmidt, A. Watson, and R. Kiesslich, “An unmet medical need: Advances in endoscopic imaging of colorectal neoplasia,” J Biophotonics4(7-8), 482–489 (2011). [CrossRef] [PubMed]
  4. T. D. Wang and J. Van Dam, “Optical biopsy: a new frontier in endoscopic detection and diagnosis,” Clin. Gastroenterol. Hepatol.2(9), 744–753 (2004). [CrossRef] [PubMed]
  5. A. Molckovsky, L. M. Song, M. G. Shim, N. E. Marcon, and B. C. Wilson, “Diagnostic potential of near-infrared Raman spectroscopy in the colon: differentiating adenomatous from hyperplastic polyps,” Gastrointest. Endosc.57(3), 396–402 (2003). [CrossRef] [PubMed]
  6. D. P. Lau, Z. Huang, H. Lui, D. W. Anderson, K. Berean, M. D. Morrison, L. Shen, and H. Zeng, “Raman spectroscopy for optical diagnosis in the larynx: Preliminary findings,” Lasers Surg. Med.37(3), 192–200 (2005). [CrossRef] [PubMed]
  7. R. Malini, K. Venkatakrishna, J. Kurien, K. M. Pai, L. Rao, V. B. Kartha, and C. M. Krishna, “Discrimination of normal, inflammatory, premalignant, and malignant oral tissue: a Raman spectroscopy study,” Biopolymers81(3), 179–193 (2006). [CrossRef] [PubMed]
  8. A. Robichaux-Viehoever, E. Kanter, H. Shappell, D. Billheimer, H. Jones, and A. Mahadevan-Jansen, “Characterization of Raman spectra measured in vivo for the detection of cervical dysplasia,” Appl. Spectrosc.61(9), 986–993 (2007). [CrossRef] [PubMed]
  9. S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Diagnostic potential of near-infrared Raman spectroscopy in the stomach: differentiating dysplasia from normal tissue,” Br. J. Cancer98(2), 457–465 (2008). [CrossRef] [PubMed]
  10. H. Lui, J. Zhao, D. I. McLean, and H. Zeng, “Real-time Raman spectroscopy for in vivo skin cancer diagnosis,” Cancer Res.72(10), 2491–2500 (2012). [CrossRef] [PubMed]
  11. H. Zeng, Y. S. Fawzy, M. A. Short, M. Tercelj, A. McWilliams, M. Petek, B. Palcic, J. Zhao, H. Lui, and S. Lam, “Combining field imaging endoscopy with point analysis spectroscopy for improving early lung cancer detection,” in Proceedings of IEEE Conference on Engineering in Medicine and Biology (Institute of Electrical and Electronics Engineers, New York, 2008), pp.1849–1850.
  12. M. G. Shim, B. C. Wilson, E. C. Marple, and M. Wach, “Study of fiber optic probes for in vivo medical Raman spectroscopy,” Appl. Spectrosc.53(6), 619–627 (1999). [CrossRef]
  13. L. F. Santos, R. Wolthuis, S. Koljenović, R. M. Almeida, and G. J. Puppels, “Fiber-optic probes for in vivo Raman spectroscopy in the high-wavenumber region,” Anal. Chem.77(20), 6747–6752 (2005). [CrossRef] [PubMed]
  14. A. Nijssen, K. Marquelin, L. F. Santos, P. J. Caspers, T. C. Bakker Schut, J. C. den Hollander, M. H. Neumann, and G. J. Puppels, “Discriminating basal cell carcinoma from perilesional skin using high wavenumber Raman spectroscopy,” J. Biomed. Opt.12(3), 034004 (2007). [CrossRef]
  15. M. A. Short, S. Lam, A. McWilliams, J. Zhao, H. Lui, and H. Zeng, “Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers,” Opt. Lett.33(7), 711–713 (2008). [CrossRef] [PubMed]
  16. M. A. Short, S. Lam, A. M. McWilliams, D. N. Ionescu, and H. Zeng, “Using laser Raman spectroscopy to reduce false positives of autofluorescence bronchoscopies: A pilot study,” J. Thorac. Oncol.6(7), 1206–1214 (2011). [CrossRef] [PubMed]
  17. M. A. Short, S. F. Lam, D. A. Owen, C. Macaulay, I. T. Tai, and H. Zeng, “Development of an endoscopic Raman spectroscopy system for the improving detection of early colonic neoplasias,” Gastrointest. Endosc.73(4), AB371–AB372 (2011). [CrossRef]
  18. J. Zhao, H. Lui, D. I. McLean, and H. Zeng, “Automated Autofluorescence Background Subtraction Algorithm for Biomedical Raman Spectroscopy,” Appl. Spectrosc.61(11), 1225–1232 (2007). [CrossRef] [PubMed]
  19. Z. Movasaghi, S. Rehman, and I. U. Rehman, “Raman spectroscopy of biological tissues,” Appl. Spectrosc. Rev.42(5), 493–541 (2007). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited