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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 22, Iss. 13 — Jun. 30, 2014
  • pp: 16606–16618

Multifocal interferometric synthetic aperture microscopy

Yang Xu, Xiong Kai Benjamin Chng, Steven G. Adie, Stephen A. Boppart, and P. Scott Carney  »View Author Affiliations


Optics Express, Vol. 22, Issue 13, pp. 16606-16618 (2014)
http://dx.doi.org/10.1364/OE.22.016606


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Abstract

There is an inherent trade-off between transverse resolution and depth of field (DOF) in optical coherence tomography (OCT) which becomes a limiting factor for certain applications. Multifocal OCT and interferometric synthetic aperture microscopy (ISAM) each provide a distinct solution to the trade-off through modification to the experiment or via post-processing, respectively. In this paper, we have solved the inverse problem of multifocal OCT and present a general algorithm for combining multiple ISAM datasets. Multifocal ISAM (MISAM) uses a regularized combination of the resampled datasets to bring advantages of both multifocal OCT and ISAM to achieve optimal transverse resolution, extended effective DOF and improved signal-to-noise ratio. We present theory, simulation and experimental results.

© 2014 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(100.6890) Image processing : Three-dimensional image processing
(110.4500) Imaging systems : Optical coherence tomography
(110.1758) Imaging systems : Computational imaging

ToC Category:
Microscopy

History
Original Manuscript: April 18, 2014
Revised Manuscript: June 16, 2014
Manuscript Accepted: June 17, 2014
Published: June 27, 2014

Virtual Issues
Vol. 9, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Yang Xu, Xiong Kai Benjamin Chng, Steven G. Adie, Stephen A. Boppart, and P. Scott Carney, "Multifocal interferometric synthetic aperture microscopy," Opt. Express 22, 16606-16618 (2014)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-22-13-16606


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