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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 22, Iss. 16 — Aug. 11, 2014
  • pp: 18833–18842

Optimal detection angle in sub-diffraction resolution photothermal microscopy: application for high sensitivity imaging of biological tissues

Jun Miyazaki, Hiromichi Tsurui, Koshi Kawasumi, and Takayoshi Kobayashi  »View Author Affiliations


Optics Express, Vol. 22, Issue 16, pp. 18833-18842 (2014)
http://dx.doi.org/10.1364/OE.22.018833


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Abstract

We evaluated the optimal detection angle for maximizing the signal to noise ratio (SNR) in sub-diffraction resolution photothermal microscopy. The angular dependent photothermal signal was calculated based on scattering theory using the temporally modulated Yukawa potential, and its detection angle and modulation frequency dependencies were analyzed. We verified the theoretical findings by imaging gold nanoparticles using laser diode based photothermal microscopy with balanced detection scheme. High-sensitivity (SNR ~40) photothermal biological imaging of a mouse brain was also demonstrated.

© 2014 Optical Society of America

OCIS Codes
(100.6640) Image processing : Superresolution
(170.5810) Medical optics and biotechnology : Scanning microscopy
(350.5340) Other areas of optics : Photothermal effects
(290.5825) Scattering : Scattering theory

ToC Category:
Microscopy

History
Original Manuscript: June 10, 2014
Revised Manuscript: July 16, 2014
Manuscript Accepted: July 20, 2014
Published: July 28, 2014

Citation
Jun Miyazaki, Hiromichi Tsurui, Koshi Kawasumi, and Takayoshi Kobayashi, "Optimal detection angle in sub-diffraction resolution photothermal microscopy: application for high sensitivity imaging of biological tissues," Opt. Express 22, 18833-18842 (2014)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-22-16-18833


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