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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 22, Iss. 5 — Mar. 10, 2014
  • pp: 5491–5511

Optimizing detection limits in whispering gallery mode biosensing

Matthew R. Foreman, Wei-Liang Jin, and Frank Vollmer  »View Author Affiliations

Optics Express, Vol. 22, Issue 5, pp. 5491-5511 (2014)

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A theoretical analysis of detection limits in swept-frequency whispering gallery mode biosensing modalities is presented based on application of the Cramér-Rao lower bound. Measurement acuity factors are derived assuming the presence of uncoloured and 1/ f Gaussian technical noise. Frequency fluctuations, for example arising from laser jitter or thermorefractive noise, are also considered. Determination of acuity factors for arbitrary coloured noise by means of the asymptotic Fisher information matrix is highlighted. Quantification and comparison of detection sensitivity for both resonance shift and broadening sensing modalities are subsequently given. Optimal cavity and coupling geometries are furthermore identified, whereby it is found that slightly under-coupled cavities outperform critically and over coupled ones.

© 2014 Optical Society of America

OCIS Codes
(000.5490) General : Probability theory, stochastic processes, and statistics
(260.5740) Physical optics : Resonance
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(110.3055) Imaging systems : Information theoretical analysis
(240.3990) Optics at surfaces : Micro-optical devices

ToC Category:

Original Manuscript: November 6, 2013
Revised Manuscript: January 6, 2014
Manuscript Accepted: February 3, 2014
Published: March 3, 2014

Virtual Issues
Vol. 9, Iss. 5 Virtual Journal for Biomedical Optics

Matthew R. Foreman, Wei-Liang Jin, and Frank Vollmer, "Optimizing detection limits in whispering gallery mode biosensing," Opt. Express 22, 5491-5511 (2014)

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