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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 22, Iss. 7 — Apr. 7, 2014
  • pp: 7617–7624

A statistical model for removing inter-device differences in spectroscopy

Lu Wang, Jong Soo Lee, Pierre Lane, E. Neely Atkinson, Andres Zuluaga, Michele Follen, Calum MacAulay, and Dennis D. Cox  »View Author Affiliations

Optics Express, Vol. 22, Issue 7, pp. 7617-7624 (2014)

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We are investigating spectroscopic devices designed to make in vivo cervical tissue measurements to detect pre-cancerous and cancerous lesions. All devices have the same design and ideally should record identical measurements. However, we observed consistent differences among them. An experiment was designed to study the sources of variation in the measurements recorded. Here we present a log additive statistical model that incorporates the sources of variability we identified. Based on this model, we estimated correction factors from the experimental data needed to eliminate the inter-device variability and other sources of variation. These correction factors are intended to improve the accuracy and repeatability of such devices when making future measurements on patient tissue.

© 2014 Optical Society of America

OCIS Codes
(030.6600) Coherence and statistical optics : Statistical optics
(120.4800) Instrumentation, measurement, and metrology : Optical standards and testing
(170.4440) Medical optics and biotechnology : ObGyn
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 23, 2014
Revised Manuscript: March 13, 2014
Manuscript Accepted: March 16, 2014
Published: March 25, 2014

Virtual Issues
Vol. 9, Iss. 6 Virtual Journal for Biomedical Optics

Lu Wang, Jong Soo Lee, Pierre Lane, E. Neely Atkinson, Andres Zuluaga, Michele Follen, Calum MacAulay, and Dennis D. Cox, "A statistical model for removing inter-device differences in spectroscopy," Opt. Express 22, 7617-7624 (2014)

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  1. J. A. Freeberg, D. M. Serachitopol, N. McKinnon, R. Price, E. N. Atkinson, D. D. Cox, C. MacAulay, R. Richards-Kortum, M. Follen, B. Pikkula, “Fluorescence and reflectance device variability throughout the progression of a phase II clinical trial to detect and screen for cervical neoplasia using a fiber optic probe,” J. Biomed. Opt. 12(3), 034015 (2007). [CrossRef] [PubMed]
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