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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 22, Iss. 9 — May. 5, 2014
  • pp: 10398–10407

Common-path diffraction optical tomography for investigation of three-dimensional structures and dynamics of biological cells

Youngchan Kim, Hyoeun Shim, Kyoohyun Kim, HyunJoo Park, Ji Han Heo, Jonghee Yoon, Chulhee Choi, Seongsoo Jang, and YongKeun Park  »View Author Affiliations


Optics Express, Vol. 22, Issue 9, pp. 10398-10407 (2014)
http://dx.doi.org/10.1364/OE.22.010398


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Abstract

We present an optical holographic micro-tomographic technique for imaging both the three-dimensional structures and dynamics of biological cells. Optical light field images of a sample, illuminated by a plane wave with various illumination angles, are measured in a common-path interferometry, and thus both the three-dimensional refractive index tomogram and two-dimensional dynamics of live biological cells are measured with extremely high sensitivity. The applicability of the technique is demonstrated through quantitative and measurements of morphological, chemical, and mechanical parameters at the individual cell level.

© 2014 Optical Society of America

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(180.3170) Microscopy : Interference microscopy
(180.6900) Microscopy : Three-dimensional microscopy

ToC Category:
Microscopy

History
Original Manuscript: February 27, 2014
Revised Manuscript: April 11, 2014
Manuscript Accepted: April 16, 2014
Published: April 22, 2014

Virtual Issues
Vol. 9, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Youngchan Kim, Hyoeun Shim, Kyoohyun Kim, HyunJoo Park, Ji Han Heo, Jonghee Yoon, Chulhee Choi, Seongsoo Jang, and YongKeun Park, "Common-path diffraction optical tomography for investigation of three-dimensional structures and dynamics of biological cells," Opt. Express 22, 10398-10407 (2014)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-22-9-10398


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