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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 3, Iss. 6 — Sep. 14, 1998
  • pp: 212–218

Imaging thermally damaged tissue by polarization sensitive optical coherence tomography

Johannes F. de Boer, Shyam M. Srinivas, Arash Malekafzali, Zhongping Chen, and J. Stuart Nelson  »View Author Affiliations


Optics Express, Vol. 3, Issue 6, pp. 212-218 (1998)
http://dx.doi.org/10.1364/OE.3.000212


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Abstract

Polarization Sensitive Optical Coherence Tomography (PS-OCT) was used to image the reduction of birefringence in biological tissue due to thermal damage. Through simultaneous detection of the amplitude of signal fringes in orthogonal polarization states formed by interference of light backscattered from turbid media and a mirror in the reference arm of a Michelson interferometer, changes in the polarization due to the optical phase delay between light propagating along the fast and slow axes of birefringent media were measured. Inasmuch as fibrous structures in many biological tissues influence the polarization state of light backscattered, PS-OCT is a potentially useful technique to image the structural properties of turbid biological materials. Birefringence of collagen, a constituent of many biological tissues, is reduced by denaturation that takes place at a temperature between 56-65 °C, thus providing an “optical marker” for thermal damage. Images showing reduction of birefringence due to thermal damage in porcine tendon and skin are presented and demonstrate the potential of PS-OCT for burn depth assessment.

© Optical Society of America

OCIS Codes
(170.0180) Medical optics and biotechnology : Microscopy
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(260.1440) Physical optics : Birefringence
(260.5430) Physical optics : Polarization

ToC Category:
Focus Issue: Optical coherence tomography

History
Original Manuscript: July 30, 1998
Published: September 14, 1998

Citation
Johannes De Boer, Shyam Srinivas, Arash Malekafzali, ZhongPing Chen, and Jerry Nelson, "Imaging thermally damaged tissue by Polarization Sensitive Optical Coherence Tomography," Opt. Express 3, 212-218 (1998)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-3-6-212


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