OSA's Digital Library

Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 3, Iss. 6 — Sep. 14, 1998
  • pp: 219–229

Optics InfoBase > Optics Express > Volume 3 > Issue 6 > Page 219

In vivo video rate optical coherence tomography

Andrew Rollins, Siavash Yazdanfar, Manish Kulkarni, Rujchai Ung-Arunyawee, and Joseph Izatt  »View Author Affiliations


Optics Express, Vol. 3, Issue 6, pp. 219-229 (1998)
http://dx.doi.org/10.1364/OE.3.000219


View Full Text Article

Enhanced HTML    Acrobat PDF (173 KB)


Advanced Search

Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

An optical coherence tomography system is described which can image up to video rate. The system utilizes a high power broadband source and real time image acquisition hardware and features a high speed scanning delay line in the reference arm based on Fourier-transform pulse shaping technology. The theory of low coherence interferometry with a dispersive delay line, and the operation of the delay line are detailed and the design equations of the system are presented. Real time imaging is demonstrated in vivo in tissues relevant to early human disease diagnosis (skin, eye) and in an important model in developmental biology (Xenopus laevis).

© Optical Society of America

[Optical Society of America ]

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Focus Issue: Optical coherence tomography

History
Original Manuscript: July 24, 1998
Published: September 14, 1998

Citation
Andrew Rollins, Siavash Yazdanfar, Manish Kulkarni, Rujchai Ung-Arunyawee, and Joseph Izatt, "In vivo video rate optical coherence tomography," Opt. Express 3, 219-229 (1998)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-3-6-219


Sort:  Journal  |  Reset  

References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  2. J. A. Izatt, M. D. Kulkarni, H.-W. Wang, K. Kobayashi, and M. V. Sivak Jr., "Optical Coherence Tomography and Microscopy in Gastrointestinal Tissues," IEEE J. Sel. Top. Quant. Elect 2, 1017-1028 (1996). [CrossRef]
  3. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography," Science 276, 2037-2039 (1997). [CrossRef] [PubMed]
  4. A. M. Sergeev, V. M. Gelikonov, G. V. Gelikonov, F. I. Feldchtein, R. V. Kuranov, and N. D. Gladkova, "In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa," Opt. Express 2, 432-440 (1997). http://epubs.osa.org/oearchive/source/2788.htm [CrossRef]
  5. E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, "High-speed optical coherence domain reflectometry," Opt. Lett. 17, 151-153 (1992). [CrossRef] [PubMed]
  6. M. D. Kulkarni, T. G. van Leeuwen, S. Yazdanfar, and J. A. Izatt, "Velocity Estimation Accuracy and Frame Rate Limitations in Color Doppler Optical Coherence Tomography," Opt. Lett. 23, 1057-1059 (1998). [CrossRef]
  7. C. B. Su, "Achieving Variation of the Optical Path Length by a Few Millimeters at Millisecond Rates for Imaging of Turbid Media and Optical Interferometry: a New Technique," Opt. Lett. 22, 665-667 (1997). [CrossRef] [PubMed]
  8. J. Ballif, R. Gianotti, P. Chavanne, R. Walti, and R. P. Salathe, "Rapid and Scalable Scans at 21 m/s in Optical Low-Coherence Reflectometry," Opt. Lett. 22, 757-759 (1997). [CrossRef] [PubMed]
  9. V. M. Gelikonov, A. M. Sergeev, G. V. Gelikonov, F. I. Feldchtein, N. D. Gladkova, J. Ioannovich, K. Fragia, and T. Pirza, "Compact Fast-Scanning OCT Device for In Vivo Biotissue Imaging," in Conference on Lasers and Electro-Optics, Vol. 9 of 1996 OSA Technical Digest Series (Optical Society of America, Washington DC, 1996), pp. 58-59.
  10. G. J. Tearney, B. E. Bouma, S. A. Boppart, B. Golubovic, E. A. Swanson, and J. G. Fujimoto, "Rapid Acquisition of In Vivo Biological Images by Use of Optical Coherence Tomography," Opt. Lett. 21, 1408-1410 (1996). [CrossRef] [PubMed]
  11. R. Windecker, M. Fleischer, B. Franze, and H. J. Tiziani, "Two Methods for Fast Coherence Tomography and Topometry," J. Mod. Optics 44, 967-977 (1997). [CrossRef]
  12. Z. A. Yasa and N. M. Amer, "A Rapid-Scanning Autocorrelation Scheme for Continuous Monitoring of Picosecond Pulses," Opt. Comm. 36, 406-408 (1981). [CrossRef]
  13. H. Harde and H. Burggraf, "Rapid Scanning Autocorrelator for Measurement of Picosecond Laser Pulses," Opt. Comm. 38, 211-215 (1981). [CrossRef]
  14. G. Xinan, M. Lambsdorff, J. Kuhl, and W. Biachang, "Fast-Scanning Autocorrelator With1-ns Scanning Range for Characterization of Mode-Locked Ion Lasers," Rev. Sci. Inst. 59, 2088-2090 (1988). [CrossRef]
  15. K. L. Sala, G. A. Kenney-Wallace, and G. E. Hall, "CW Autocorrelation Measurements of Picosecond Laser Pulses," IEEE J. Quant. Elect. QE-16, 990-996 (1980). [CrossRef]
  16. Y. Ishida, T. Yajima, and Y. Tanaka, "Rapid-Scan Autocorrelator for Monitoring CW Mode-Locked Dye Laser Pulses," Jap. J. Appl. Phys. 19, L289-L292 (1980). [CrossRef]
  17. M. Yamaguchi and K. Hirabayashi, "Variable Optical Delay Line Based on a Birefringent Planar Optical Platform," Opt. Lett. 20, 644-646 (1995). [CrossRef] [PubMed]
  18. A. M. Weiner, D. E. Leaird, J. S. Patel, and J. R. Wullert, "Programmable Femtosecond Pulse Shaping by Use of a Multielement Liquid-Crystal Phase Modulator," Opt. Lett. 15, 326-328 (1990). [CrossRef] [PubMed]
  19. K. F. Kwong, D. Yankelevich, K. C. Chu, J. P. Heritage, and A. Dienes, "400-Hz Mechanical Scanning Optical Delay Line," Opt. Lett. 18, 558-560 (1993). [CrossRef] [PubMed]
  20. G. J. Tearney, B. E. Bouma, and J. G. Fujimoto, "High Speed Phase-and Group-Delay Scanning with a Grating-Based Phase Control Delay Line," Opt. Lett. 22, 1811-1813 (1997). [CrossRef]
  21. M. D. Kulkarni, C. W. Thomas, and J. A. Izatt, "Image Enhancement in Optical Coherence Tomography Using Deconvolution," Elect. Lett. 33, 1365-1367 (1997). [CrossRef]
  22. M. R. Hee, M. S. Thesis, Massachusetts Institute of Technology, (1992).
  23. O. E. Martinez, "3000 Times Grating Compressor with Positive Group Velocity Dispersion: Application to Fiber Compensation in 1.3-1.6 um Region," IEEE J. Quant. Elect. QE-23, 59-64 (1987). [CrossRef]
  24. P. R. Morkel, R. I. Laming, and D. N. Payne, "Noise characteristics of High-Power Doped-Fibre Superluminescent Sources," Elect. Lett. 26, 96-98 (1990). [CrossRef]
  25. A. Gh. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, "Transversal and Longitudinal Images from the Retina of the Living Eye Using Low Coherence Reflectometry," J. Biomed. Opt. 3, 12-20 (1998). [CrossRef] [PubMed]
  26. Animal experiments were conducted under protocols approved by the Institutional Animal Care and Use committee of the Case Western Reserve University School of Medicine.
  27. S. A. Boppart, B. E. Bouma, M. E. Brezinski, G. J. Tearney, and J. G. Fujimoto, "Imaging Developing Neural Morphology Using Optical Coherence Tomography," J. Neurosci. Methods 70, 65-72 (1996). [CrossRef] [PubMed]
  28. S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, "Noninvasive Assessment of the Developing Xenopus Cardiovascular System Using Optical Coherence Tomography," Proc. Natl. Acad. Sci. 94, 4256-4261 (1997). [CrossRef] [PubMed]
  29. S. Yazdanfar, M. D. Kulkarni, and J. A. Izatt, "High Resolution Imaging of In Vivo Cardiac Dynamics Using Color Doppler Optical Coherence Tomography," Opt. Express 1, 424-431 (1997). http://epubs.osa.org/oearchive/source/2834.htm [CrossRef] [PubMed]

Cited By

 Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Multimedia

Multimedia FilesRecommended Software
» Media 1: MOV (776 KB)      QuickTime
» Media 2: MOV (136 KB)      QuickTime
» Media 3: MOV (304 KB)      QuickTime

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited