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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 3, Iss. 6 — Sep. 14, 1998
  • pp: 251–256

Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography

Jennifer Kehlet Barton, Ashley J. Welch, and Joseph A. Izatt  »View Author Affiliations

Optics Express, Vol. 3, Issue 6, pp. 251-256 (1998)

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A non-invasive method of imaging laser irradiated blood vessels has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders. The CDOCT system used a 1280 nm center wavelength superluminescent diode. A 585 nm, 360 μs pulsed dye laser was used to irradiate hamster dorsal skin flap window preparations. Irradiation sites were imaged with CDOCT prior to, immediately after, and 24 hours after laser irradiation. The processed CDOCT signal provided an estimate of the blood flow velocity. An increase in the blood vessel backscattered signal was observed as blood or vessel walls were coagulated. A decrease in damaged blood vessel reflectivity occurred after twenty four hours.

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OCIS Codes
(170.1870) Medical optics and biotechnology : Dermatology
(170.3660) Medical optics and biotechnology : Light propagation in tissues

ToC Category:
Focus Issue: Optical coherence tomography

Original Manuscript: July 30, 1998
Published: September 14, 1998

Jennifer Barton, Ashley Welch, and Joseph Izatt, "Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography," Opt. Express 3, 251-256 (1998)

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