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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 4, Iss. 10 — May. 10, 1999
  • pp: 372–382

Truncated Newton’s optimization scheme for absorption and fluorescence optical tomography: Part II reconstruction from synthetic measurements

R. Roy and E. M. Sevick-Muraca  »View Author Affiliations


Optics Express, Vol. 4, Issue 10, pp. 372-382 (1999)
http://dx.doi.org/10.1364/OE.4.000372


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Abstract

Using two dimensional synthetic frequency-domain measurements, the inverse imaging problem is solved for absorption and fluorescence lifetime mapping with the truncated Newton’s optimization scheme developed in Part I of this contribution. Herein, we present reconstructed maps of absorption owing to a fluorophore from excitation and emission measurements which detail the presence of tissue heterogeneities characterized by tenfold increase in fluorescent contrast agent. Our results confirm that fluorescence provides superior mapping of heterogeneities over excitation measurements. Using emission measurements we then map fluorescent lifetime under conditions of tenfold uptake of contrast agent in tissue heterogeneities. The ability to map fluorescent quenching and lengthening of contrast agents facilitates the solution of the inverse problem and further improves the ability to reconstruct tissue heterogeneities.

© Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(260.2510) Physical optics : Fluorescence

ToC Category:
Research Papers

History
Original Manuscript: April 9, 1999
Published: May 10, 1999

Citation
R. Roy and E. Sevick-Muraca, "Truncated Newton's optimization scheme for absorption and fluorescence optical tomography: Part II Reconstruction from synthetic measurements," Opt. Express 4, 372-382 (1999)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-4-10-372


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References

  1. R. Roy and E.M. Sevick-Muraca, "Truncated Newtons optimization scheme for absorption and fluorescence optical tomography: Part I- Theory and formulation," Opt. Express 4, 353-371 (1999); http://www.opticsexpress.org/oearchive/source/9268.htm. [CrossRef] [PubMed]
  2. T. L. Troy, D. L. Page and E. M. Sevick-Muraca, "Optical properties of normal and diseased breast tissues: prognosis for optical mammography," J. Biomedical Opt. 1, 342-355 (1996). [CrossRef]
  3. E. M. Sevick-Muraca, G. Lopez, T. L. Troy, J. S. Reynolds and C. L. Hutchinson, "Fluorescence and absorption contrast mechanisms for biomedical optical imaging using frequency-domain techniques," Photochem. Photobiolo. 66, 55-64 (1997). [CrossRef]
  4. R. Cubeddu, G. Canti, A. Pifferi, P. Taroni and G. Valentini, "Fluorescence lifetime imaging of experimental tumors in hematoporhyrin derivate-sensitized mice," Photochem. Photobiol. 66, 229-236 (1997). [CrossRef] [PubMed]
  5. D. Y. Paithankar, A. U. Chen, B. W. Pogue, M. S. Patterson and E. M. Sevick-Muraca, "Imaging of fluorescent yield and lifetime from multiply scattered light re-emitted from tissues and other random media," Appl. Opt. 36, 2260-2272 (1997). [CrossRef] [PubMed]
  6. M. A. OLeary, D. A. Boas, B. Chance and A.G. Yodh, "Fluorescence lifetime imaging in turbid media," Opt. Lett. 21, 158-160 (1996). [CrossRef]
  7. E. M. Sevick-Muraca, C. L. Hutchinson and D.Y. Paithankar, "Optical Tissue Biodiagnostics Using Fluorescence Lifetime," Opt. Photon. News 7, (1996) pp 25-28. [CrossRef]
  8. H. Jiang, "Frequency-domain fluorescent diffusion tomography: a finite-element based algorithm and simulations," Appl. Opt. 37, 5337-5343 (1998). [CrossRef]
  9. M. J. Eppstein, D. E. Dougherty, D. J. Hawrysz and E. M. Sevick-Muraca, "Three-dimensional optical tomography," Optical Tomography and Spectroscopy of Tissue III, B. Chance, R. R. Alfano, and B. J. Tromberg (eds.). Proc. Soc. Photo-Opt. Instrum. Eng., 3597: 000-000 (1999).
  10. M. Schweiger and S. R. Arridge, "Comparison of two- and three- dimensional reconstruction methods in optical tomography," Appl. Opt. 37, 7419-7428 (1998). [CrossRef]
  11. J. S. Reynolds, T. L. Troy and E. M. Sevick-Muraca, "Multi-pixel techniques for frequency-domain photon migration imaging," Biotech. Prog. 13, 669-680 (1997). [CrossRef]
  12. S., Troy, T. L., Thompson, A., Mayer, R., Thompson, A. B., Waters, D. J., Cornell, K.K., Snyder, P.W., and E. M. Sevick-Muraca, "Multi-pixel frequency-domain of spontaneous canine breast disease using fluorescent agents," Optical Tomography and Spectroscopy of Tissue III, B. Chance, R. R. Alfano, and B. J. Tromberg (eds.). Proc. Soc. Photo-Opt. Instrum. Eng., 3597: 000-000, 1999.

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