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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 4, Iss. 11 — May. 24, 1999
  • pp: 449–456

On probing molecular monolayers: a spectroscopic optical waveguide approach of ultra-sensitivity

Sergio B. Mendes and S. Scott Saavedra  »View Author Affiliations

Optics Express, Vol. 4, Issue 11, pp. 449-456 (1999)

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A broadband, multichannel, single-mode, planar waveguide based spectrometer was developed for probing molecular monolayers. A protein sub-monolayer (thickness h ≅ 3 nm, imaginary part of refractive index kl ≤ 0.01) immobilized on the waveguide surface was characterized by the waveguide attenuated total reflection (ATR) spectrometer. A sensitivity enhancement of 4 orders of magnitude, compared to conventional transmission measurements, has been experimentally achieved in the characterization of ultra-thin films. In addition, polarized spectroscopic measurements at the TE and TM waveguide modes were implemented to determine the average orientation angle of the adsorbed molecules. The work developed here is a new research tool for the investigation of some fundamental aspects of molecular films and a novel platform to develop new technological devices of high sensitivity and selectivity such as biosensors.

© Optical Society of America

OCIS Codes
(240.0240) Optics at surfaces : Optics at surfaces
(240.6690) Optics at surfaces : Surface waves

ToC Category:
Focus Issue: Sensing

Original Manuscript: April 5, 1999
Published: May 24, 1999

Sergio B. Mendes and S. Saavedra, "On probing molecular monolayers: a spectroscopic optical waveguide approach of ultra-sensitivity," Opt. Express 4, 449-456 (1999)

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