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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 4, Iss. 8 — Apr. 12, 1999
  • pp: 308–314

Non-invasive optical mapping of the piglet brain in real time

Sergio Fantini, Maria Angela Franceschini, Enrico Gratton, Dennis Hueber, Warren Rosenfeld, Dev Maulik, Phillip G. Stubblefield, and Miljan R. Stankovic  »View Author Affiliations

Optics Express, Vol. 4, Issue 8, pp. 308-314 (1999)

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We have performed non-invasive, real-time optical mapping of the piglet brain during a subcortical injection of autologous blood. The time resolution of the optical maps is 192 ms, thus allowing us to generate a real-time video of the growing subcortical hematoma. The increased absorption at the site of blood injection is accompanied by a decreased absorption at the contralateral brain side. This contralateral decrease in the optical absorption and the corresponding time traces of the cerebral hemoglobin parameters are consistent with a reduced cerebral blood flow caused by the increased intracranial pressure.

© Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5280) Medical optics and biotechnology : Photon migration

ToC Category:
Focus Issue: Biomedical diffuse optical tomography

Original Manuscript: March 10, 1999
Published: April 12, 1999

Sergio Fantini, Maria Franceschini, Enrico Gratton, Dennis Hueber, Warren Rosenfeld, Dev Maulik, Phillip Stubblefield, and Mikjan Stankovic, "Non-invasive optical mapping of the piglet brain in real time," Opt. Express 4, 308-314 (1999)

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